Heparin-sensitive and nonsensitive forms of thrombin

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Abstract

Two forms of thrombin (Ts-thrombin and Tp-thrombin) were found with respect to heparin sensitivity. Inactivation of Ts-thrombin by antithrombin-III was facilitated with heparin, whereas inactivation of Tp-thrombin was not. Both thrombins were bound to heparin in a Sephadex G-200 gel filtration experiment. Ts-thrombin proved to be more stable and was better protected by heparin against heat inactivation at 54 °C than Tp-thrombin.

Original languageEnglish
Pages (from-to)62-68
Number of pages7
JournalBBA - Protein Structure
Volume400
Issue number1
DOIs
Publication statusPublished - Jul 21 1975

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ASJC Scopus subject areas

  • Medicine(all)

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