Heparin rebound phenomenon much ado about nothing?

P. Martin, F. Horkay, N. K. Gupta, C. Gebitekin, D. R. Walker

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Significant postoperative bleeding following open-heart surgery is often ascribed to the so-called heparin 'rebound' phenomenon and as such is treated with additional empiric doses of protamine sulphate. However, inappropriate protamine administration has been reported to be associated with acute pulmonary hypertension. The efficacy of heparin reversal was investigated in 42 patients undergoing open-heart surgery. The standard heparin bolus of 3 mg/kg body weight (4.1 IU/ml blood) administered before cardiopulmonary bypass was countered at the end of bypass using an empirical equivalent (3 mg/kg) of protamine. This regimen resulted in complete heparin neutralization (measured by the Hepcon HMS [Hemotec Inc., Englewood, CO, USA]) 15min after protamine administration in all 42 patients, but heparin levels (0.4IU/ml) were transiently detectable (duration

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalBlood Coagulation and Fibrinolysis
Volume3
Issue number2
Publication statusPublished - 1992

Fingerprint

Protamines
Heparin
Thoracic Surgery
Carbon Monoxide
Cardiopulmonary Bypass
Pulmonary Hypertension
Body Weight
Hemorrhage

ASJC Scopus subject areas

  • Hematology

Cite this

Martin, P., Horkay, F., Gupta, N. K., Gebitekin, C., & Walker, D. R. (1992). Heparin rebound phenomenon much ado about nothing? Blood Coagulation and Fibrinolysis, 3(2), 187-191.

Heparin rebound phenomenon much ado about nothing? / Martin, P.; Horkay, F.; Gupta, N. K.; Gebitekin, C.; Walker, D. R.

In: Blood Coagulation and Fibrinolysis, Vol. 3, No. 2, 1992, p. 187-191.

Research output: Contribution to journalArticle

Martin, P, Horkay, F, Gupta, NK, Gebitekin, C & Walker, DR 1992, 'Heparin rebound phenomenon much ado about nothing?', Blood Coagulation and Fibrinolysis, vol. 3, no. 2, pp. 187-191.
Martin P, Horkay F, Gupta NK, Gebitekin C, Walker DR. Heparin rebound phenomenon much ado about nothing? Blood Coagulation and Fibrinolysis. 1992;3(2):187-191.
Martin, P. ; Horkay, F. ; Gupta, N. K. ; Gebitekin, C. ; Walker, D. R. / Heparin rebound phenomenon much ado about nothing?. In: Blood Coagulation and Fibrinolysis. 1992 ; Vol. 3, No. 2. pp. 187-191.
@article{ec3513a4efa442edb79aa7d751c73314,
title = "Heparin rebound phenomenon much ado about nothing?",
abstract = "Significant postoperative bleeding following open-heart surgery is often ascribed to the so-called heparin 'rebound' phenomenon and as such is treated with additional empiric doses of protamine sulphate. However, inappropriate protamine administration has been reported to be associated with acute pulmonary hypertension. The efficacy of heparin reversal was investigated in 42 patients undergoing open-heart surgery. The standard heparin bolus of 3 mg/kg body weight (4.1 IU/ml blood) administered before cardiopulmonary bypass was countered at the end of bypass using an empirical equivalent (3 mg/kg) of protamine. This regimen resulted in complete heparin neutralization (measured by the Hepcon HMS [Hemotec Inc., Englewood, CO, USA]) 15min after protamine administration in all 42 patients, but heparin levels (0.4IU/ml) were transiently detectable (duration",
author = "P. Martin and F. Horkay and Gupta, {N. K.} and C. Gebitekin and Walker, {D. R.}",
year = "1992",
language = "English",
volume = "3",
pages = "187--191",
journal = "Blood Coagulation and Fibrinolysis",
issn = "0957-5235",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Heparin rebound phenomenon much ado about nothing?

AU - Martin, P.

AU - Horkay, F.

AU - Gupta, N. K.

AU - Gebitekin, C.

AU - Walker, D. R.

PY - 1992

Y1 - 1992

N2 - Significant postoperative bleeding following open-heart surgery is often ascribed to the so-called heparin 'rebound' phenomenon and as such is treated with additional empiric doses of protamine sulphate. However, inappropriate protamine administration has been reported to be associated with acute pulmonary hypertension. The efficacy of heparin reversal was investigated in 42 patients undergoing open-heart surgery. The standard heparin bolus of 3 mg/kg body weight (4.1 IU/ml blood) administered before cardiopulmonary bypass was countered at the end of bypass using an empirical equivalent (3 mg/kg) of protamine. This regimen resulted in complete heparin neutralization (measured by the Hepcon HMS [Hemotec Inc., Englewood, CO, USA]) 15min after protamine administration in all 42 patients, but heparin levels (0.4IU/ml) were transiently detectable (duration

AB - Significant postoperative bleeding following open-heart surgery is often ascribed to the so-called heparin 'rebound' phenomenon and as such is treated with additional empiric doses of protamine sulphate. However, inappropriate protamine administration has been reported to be associated with acute pulmonary hypertension. The efficacy of heparin reversal was investigated in 42 patients undergoing open-heart surgery. The standard heparin bolus of 3 mg/kg body weight (4.1 IU/ml blood) administered before cardiopulmonary bypass was countered at the end of bypass using an empirical equivalent (3 mg/kg) of protamine. This regimen resulted in complete heparin neutralization (measured by the Hepcon HMS [Hemotec Inc., Englewood, CO, USA]) 15min after protamine administration in all 42 patients, but heparin levels (0.4IU/ml) were transiently detectable (duration

UR - http://www.scopus.com/inward/record.url?scp=0026539028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026539028&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 187

EP - 191

JO - Blood Coagulation and Fibrinolysis

JF - Blood Coagulation and Fibrinolysis

SN - 0957-5235

IS - 2

ER -