Heparan sulfate proteoglycan (HSPG) can take part in cell division: inside and outside

Bettina Ughy, Ildiko Schmidthoffer, Laszlo Szilak

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Prior to the cytokinesis, the cell–matrix interactions should be disrupted, and the mitotic cells round up. Prerequisite of mitosis, the centrosomes duplicate, spindle fibers are generated and move away from each other to opposite sides of the cells marking the cell poles. Later, an invagination in the plasma membrane is formed a few minutes after anaphase. This furrow ingression is driven by a contractile actomyosin ring, whose assembly is regulated by RhoA GTPase. At the completion of cytokinesis, the two daughter cells are still connected by a thin intercellular bridge, which is subjected to abscission, as the terminal step of cytokinesis. Here, it is overviewed, how syndecan-4, a transmembrane, heparan sulfate proteoglycan, can contribute to these processes in a phosphorylation-dependent manner.

Original languageEnglish
Pages (from-to)865-871
Number of pages7
JournalCellular and Molecular Life Sciences
Volume76
Issue number5
DOIs
Publication statusPublished - Mar 15 2019

Keywords

  • Dynamin
  • ESCRT
  • Microtubules
  • Midbody
  • Mitotic rounding
  • Polyploidy
  • Protein phosphorylation
  • Small GTPases
  • Tiam1

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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