Haemostasis eltérések ischaemiás stroke-ban.

Translated title of the contribution: Hemostatic abnormalities in ischemic stroke

M. Misz, L. Oláh, J. Kappelmayer, G. Blaskó, M. Udvardy, I. Fekete, T. Csépány, E. Ajzner, L. Csiba

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The authors studied whether haemostatic abnormalities connected with the development of cerebral circulatory disturbances can be demonstrated in young stroke patients in whom Doppler and angiographic examination failed to reveal deviations indicative of stroke. They determined the in vivo activation of the coagulation system (TAT, F 1 + 2), the degree of secondary fibrinolysis (D-dimer), the plasma levels of the markers of fibrinolysis, with special regard to inhibitors: plasminogen activator inhibitor (PAI-1), alpha 2 antiplasmin (alpha 2 AP), alpha 2 macroglobulin (alpha 2 M), the frequency of pathologic serum lipoprotein (a)-Lp(a)-values and the association of PAI-1 and Lp(a) with the fibrinolytic system. They conclude that in the acute phase of the disease, the TAT and F 1 + 2 values were significantly elevated compared to the control, without change in the D-dimer value. The results suggest that in the tested period increased thrombin generation dominated and it significantly surpassed plasmin activity since the D-dimer values of that period did not indicate substantial increase in secondary fibrinolysis. The results of the study were separately analyzed in acute, chronic TIA and stroke groups. In the TIA and acute group the F 1 + 2 values, while in stroke the TAT values were more elevated. The in vitro fibrinolytic capacity of the patients significantly decreased compared to controls, showing significant correlation with the Lp(a) level, but not with the PAI value. Examination of the marker molecules renders possible to assess the degree of hypercoaguability and of endogenous lysis. Their knowledge is held important for judging the progression of the disease and the therapeutic consequences.

Original languageHungarian
Pages (from-to)2503-2507
Number of pages5
JournalOrvosi Hetilap
Volume139
Issue number42
Publication statusPublished - Oct 18 1998

Fingerprint

Hemostatics
Plasminogen Activator Inhibitor 1
Fibrinolysis
Stroke
alpha-2-Antiplasmin
alpha-Macroglobulins
Lipoprotein(a)
Fibrinolysin
Acute Disease
Thrombin
Disease Progression
Serum
fibrin fragment D
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Haemostasis eltérések ischaemiás stroke-ban. / Misz, M.; Oláh, L.; Kappelmayer, J.; Blaskó, G.; Udvardy, M.; Fekete, I.; Csépány, T.; Ajzner, E.; Csiba, L.

In: Orvosi Hetilap, Vol. 139, No. 42, 18.10.1998, p. 2503-2507.

Research output: Contribution to journalArticle

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