Hemorheological follow-up after splenectomy and spleen autotransplantation in mice

I. Mikó, N. Németh, Sandor Sipka, E. Bráth, Katalin Peto, Adrienn Gulyas, I. Furka, Robert Zhong

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We previously reported on a spleen autotransplantation model in mice, with spleen function studies at 6 weeks. The present study was undertaken to investigate long-term hemorheological functions. A/J and BALB/c inbred mice were divided into four groups: control, sham surgery (SH), splenectomy (SE), and spleen autotransplantation (AU). Hematological and hemorheological parameters were determined. Leukocyte counts in the SE and AU groups were significantly higher than in controls, while hematocrit levels were markedly lower. Mean erythrocyte volume did not change significantly. Platelet counts in the AU group were significantly lower, and red blood cell deformability was significantly worse in the SE group. The AU group also had increased cell transit time, but it was less than that in the SE group. The SE group showed the highest fibrinogen levels. We conclude that there are some consistent differences in hematological parameters between splenectomy and spleen autotransplantation. These data suggest that spleen autotransplantation may partially restore hemorheological functions following splenectomy.

Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalMicrosurgery
Volume26
Issue number1
DOIs
Publication statusPublished - 2006

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Autologous Transplantation
Splenectomy
Spleen
Erythrocyte Volume
Platelet Count
Leukocyte Count
Hematocrit
Fibrinogen
Erythrocytes
Control Groups

ASJC Scopus subject areas

  • Surgery

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Hemorheological follow-up after splenectomy and spleen autotransplantation in mice. / Mikó, I.; Németh, N.; Sipka, Sandor; Bráth, E.; Peto, Katalin; Gulyas, Adrienn; Furka, I.; Zhong, Robert.

In: Microsurgery, Vol. 26, No. 1, 2006, p. 38-42.

Research output: Contribution to journalArticle

Mikó, I. ; Németh, N. ; Sipka, Sandor ; Bráth, E. ; Peto, Katalin ; Gulyas, Adrienn ; Furka, I. ; Zhong, Robert. / Hemorheological follow-up after splenectomy and spleen autotransplantation in mice. In: Microsurgery. 2006 ; Vol. 26, No. 1. pp. 38-42.
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