Hemorheological changes caused by intermittent Pringle (Baron) maneuver in beagle canine model

A. Furka, N. Nemeth, A. Gulyas, E. Brath, K. Peto, I. E. Takacs, I. Furka, P. Sapy, I. Miko

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In liver resection operations the Pringle (Baron) maneuver can be used for temporary ischemia by clamping the hepatoduodenal ligament intermittently. In this beagle canine model we investigated whether hemorheological parameters may alter in systemic, portal and hepatic venous blood and in arterial samples during-after Pringle maneuvers. In Pringle Group unilateral femoral artery and external jugular vein were cannulated. From median laparotomy the hepatoduodenal ligament was exposed. The portal venous system was catheterized via a mesenteric vein and through the inferior caval vein a catheter was led to the hepatic veins. After stabilization, a 15-minute Pringle maneuver was carried out three times with 5-minute interpolated reperfusion periods. In Control Group Pringle maneuvers were not made. Before and after Pringle maneuvers parallel blood samples were taken from the cannulated vessels for determining hematological parameters and erythrocyte aggregation. Following Pringle maneuvers erythrocyte deformability, blood and plasma viscosity were also tested. The results showed that besides systemic hemorheological effects of the intermittent Pringle maneuver local leukocyte count, hematocrit and erythrocyte aggregation index altered mainly in portal venous blood, depending on the repeating number of the maneuvers. Thus, investigations of hemorheological parameters might be useful to determine the optimal duration of the Pringle maneuver.

Original languageEnglish
Pages (from-to)177-189
Number of pages13
JournalClinical Hemorheology and Microcirculation
Volume40
Issue number3
DOIs
Publication statusPublished - 2008

Fingerprint

Erythrocyte Aggregation
Canidae
Ligaments
Erythrocyte Deformability
Portal System
Mesenteric Veins
Venae Cavae
Blood Viscosity
Erythrocyte Indices
Hepatic Veins
Liver
Jugular Veins
Femoral Artery
Leukocyte Count
Hematocrit
Constriction
Laparotomy
Reperfusion
Veins
Ischemia

Keywords

  • Erythrocyte aggregation
  • Hemorheology
  • Ischemia-reperfusion
  • Pringle maneuver

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Hemorheological changes caused by intermittent Pringle (Baron) maneuver in beagle canine model. / Furka, A.; Nemeth, N.; Gulyas, A.; Brath, E.; Peto, K.; Takacs, I. E.; Furka, I.; Sapy, P.; Miko, I.

In: Clinical Hemorheology and Microcirculation, Vol. 40, No. 3, 2008, p. 177-189.

Research output: Contribution to journalArticle

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