Hemolytic uremic syndrome complicating whooping cough

Vesna Stojanović, Nenad Barišić, Aleksandra Doronjski, Dorottya Csuka, Z. Prohászka

Research output: Contribution to journalArticle

Abstract

Introduction We shall present a case of a two-month old infant who has developed a haemolytic uremic syndrome as an atypical complication of Bordetella pertussis infection. The observation that the development of haemolytic uremic syndrome is a late complication of Bordetella pertussis infection may be a clue for further studies. Case outline A two-month-old female infant was admitted to the hospital because of fever, intensive cough, shortness of breath and poor feeding. Real-time polymerase chain reaction (PCR) for Bordetella pertussis was positive. A macrolide was introduced in therapy. On the eighth hospital day, the infant’s condition improved, she became afebrile and eupneic. On the 16th hospital day, she developed signs of progressive respiratory distress and oliguric acute kidney injury. Hemolytic uremic syndrome (HUS) was diagnosed, so the therapy with the fresh frozen plasma (FFP) transfusion, therapeutic plasma exchange and peritoneal dialysis was initiated. Levels of ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) were decreased, while the levels of factor H, factor B, and factor I were normal. Despite the full supportive and targeted care, severe multiple organ failure had developed and on the 24th hospital day the infant died. Conclusion Further studies are necessary to identify the mechanism of potential interaction between pertussis toxins, pathophysiology of the infection and the interaction of complement activation, coagulation and the regulation of these cascades.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalSrpski Arhiv za Celokupno Lekarstvo
Volume147
Issue number1-2
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Hemolytic-Uremic Syndrome
Whooping Cough
Bordetella pertussis
Bordetella Infections
Thrombospondin 1
Disintegrins
Complement Factor H
Plasma Exchange
Multiple Organ Failure
Complement Activation
Pertussis Toxin
Macrolides
Metalloproteases
Peritoneal Dialysis
Acute Kidney Injury
Cough
Dyspnea
Real-Time Polymerase Chain Reaction
Fever
Therapeutics

Keywords

  • Hemolytic uremic syndrome
  • Infant
  • Pertussis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hemolytic uremic syndrome complicating whooping cough. / Stojanović, Vesna; Barišić, Nenad; Doronjski, Aleksandra; Csuka, Dorottya; Prohászka, Z.

In: Srpski Arhiv za Celokupno Lekarstvo, Vol. 147, No. 1-2, 01.01.2019, p. 89-93.

Research output: Contribution to journalArticle

Stojanović, V, Barišić, N, Doronjski, A, Csuka, D & Prohászka, Z 2019, 'Hemolytic uremic syndrome complicating whooping cough', Srpski Arhiv za Celokupno Lekarstvo, vol. 147, no. 1-2, pp. 89-93. https://doi.org/10.2298/SARH171207058S
Stojanović, Vesna ; Barišić, Nenad ; Doronjski, Aleksandra ; Csuka, Dorottya ; Prohászka, Z. / Hemolytic uremic syndrome complicating whooping cough. In: Srpski Arhiv za Celokupno Lekarstvo. 2019 ; Vol. 147, No. 1-2. pp. 89-93.
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