Az N-acetilcisztein hemodinamikai hatása és ischaemiás prekondicionálás máj ischaemia-reperfúzió modellen

Translated title of the contribution: Hemodynamic effects of N-acetylcystein and ischemic preconditioning in a liver ischemia-reperfusion model

Subhamay Ghosh, János Baumann, Boglárka Falusi, L. Bogár, E. Rőth, J. Gál

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of the study was to investigate whether repeated ischemic preconditioning or N-acetylcystein (NAC) prevents ischemic-reperfusion injury as determined by having favourable hemodynamic effects during reperfusion in canine livers. Methods: The control group (n = 10) underwent 60 minutes of hepatic ischemia followed by 180 minutes reperfusion. In the NAC group (n = 5) 150 mg kg-1 of NAC was administered intravenously before inducing ischemia. In the preconditioned group (n = 5) animals received ischemic preconditioning (10 minutes of ischemia followed by 10 minutes of reperfusion repeated three times) before clamping the portal triad. Results: 18 dogs survived the study period. One dog in the NAC group died due to circulatory failure unresponsive to inotropic drugs. The cardiac index and the intrathoracic blood volume index were significantly higher in the preconditioning group compared to the controls throughout the study period. Conclusions: Repeated ischemic preconditioning might improve hemodynamic parameters, whereas we were unable to find any significant differences between the groups regarding N-acetylcystein.

Original languageHungarian
Pages (from-to)2245-2249
Number of pages5
JournalOrvosi Hetilap
Volume149
Issue number47
DOIs
Publication statusPublished - Nov 23 2008

Fingerprint

Ischemic Preconditioning
Reperfusion
Ischemia
Hemodynamics
Liver
Dogs
Blood Volume
Reperfusion Injury
Constriction
Canidae
Shock
Control Groups
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az N-acetilcisztein hemodinamikai hatása és ischaemiás prekondicionálás máj ischaemia-reperfúzió modellen. / Ghosh, Subhamay; Baumann, János; Falusi, Boglárka; Bogár, L.; Rőth, E.; Gál, J.

In: Orvosi Hetilap, Vol. 149, No. 47, 23.11.2008, p. 2245-2249.

Research output: Contribution to journalArticle

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