Hemodynamic effects of calcium-sensitizing agents

Ágnes Végh, Julius Gy Papp, Éva Udvary, Károly Kaszala

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27 Citations (Scopus)

Abstract

Over the last few years the development of calcium-sensitizing agents has led to a new approach to the treatment of congestive heart failure (CHF). These novel inotropic agents act directly on the contractile protein systems and correct the reduced responsiveness of the myofilaments to calcium. The resultant favorable inotropic activity of this new class of cardiotonic agents may represent an important pharmacologic approach to the future treatment of acute and chronic CHF. This briefreview summarizes the cardiotonic effects of calcium sensitizers, with particular emphasis on the hemodynamic actions of these drugs in various in vitro and in vivo heart preparations. We also attempt to draw conclusions for the therapeutic exploitation of these agents and delineate their possible role in the therapy of CHF.

Original languageEnglish
Pages (from-to)S20-S31
JournalJournal of cardiovascular pharmacology
Volume26
Publication statusPublished - Jan 1 1995

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Keywords

  • Calcium sensitizers
  • Heart failure
  • Hemodynamics
  • Inotropic agents
  • Systolic dysfunction

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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