Hemodynamic effects of calcium-sensitizing agents

A. Végh, J. Papp, Éva Udvary, Károly Kaszala

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Over the last few years the development of calcium-sensitizing agents has led to a new approach to the treatment of congestive heart failure (CHF). These novel inotropic agents act directly on the contractile protein systems and correct the reduced responsiveness of the myofilaments to calcium. The resultant favorable inotropic activity of this new class of cardiotonic agents may represent an important pharmacologic approach to the future treatment of acute and chronic CHF. This briefreview summarizes the cardiotonic effects of calcium sensitizers, with particular emphasis on the hemodynamic actions of these drugs in various in vitro and in vivo heart preparations. We also attempt to draw conclusions for the therapeutic exploitation of these agents and delineate their possible role in the therapy of CHF.

Original languageEnglish
Pages (from-to)S20-S31
JournalJournal of Cardiovascular Pharmacology
Volume26
Publication statusPublished - 1995

Fingerprint

Cardiotonic Agents
Heart Failure
Hemodynamics
Calcium
Contractile Proteins
Myofibrils
Therapeutics
Pharmaceutical Preparations
In Vitro Techniques

Keywords

  • Calcium sensitizers
  • Heart failure
  • Hemodynamics
  • Inotropic agents
  • Systolic dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Hemodynamic effects of calcium-sensitizing agents. / Végh, A.; Papp, J.; Udvary, Éva; Kaszala, Károly.

In: Journal of Cardiovascular Pharmacology, Vol. 26, 1995, p. S20-S31.

Research output: Contribution to journalArticle

Végh, A. ; Papp, J. ; Udvary, Éva ; Kaszala, Károly. / Hemodynamic effects of calcium-sensitizing agents. In: Journal of Cardiovascular Pharmacology. 1995 ; Vol. 26. pp. S20-S31.
@article{9517d4845e3e475abacbcc56ab967aa9,
title = "Hemodynamic effects of calcium-sensitizing agents",
abstract = "Over the last few years the development of calcium-sensitizing agents has led to a new approach to the treatment of congestive heart failure (CHF). These novel inotropic agents act directly on the contractile protein systems and correct the reduced responsiveness of the myofilaments to calcium. The resultant favorable inotropic activity of this new class of cardiotonic agents may represent an important pharmacologic approach to the future treatment of acute and chronic CHF. This briefreview summarizes the cardiotonic effects of calcium sensitizers, with particular emphasis on the hemodynamic actions of these drugs in various in vitro and in vivo heart preparations. We also attempt to draw conclusions for the therapeutic exploitation of these agents and delineate their possible role in the therapy of CHF.",
keywords = "Calcium sensitizers, Heart failure, Hemodynamics, Inotropic agents, Systolic dysfunction",
author = "A. V{\'e}gh and J. Papp and {\'E}va Udvary and K{\'a}roly Kaszala",
year = "1995",
language = "English",
volume = "26",
pages = "S20--S31",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Hemodynamic effects of calcium-sensitizing agents

AU - Végh, A.

AU - Papp, J.

AU - Udvary, Éva

AU - Kaszala, Károly

PY - 1995

Y1 - 1995

N2 - Over the last few years the development of calcium-sensitizing agents has led to a new approach to the treatment of congestive heart failure (CHF). These novel inotropic agents act directly on the contractile protein systems and correct the reduced responsiveness of the myofilaments to calcium. The resultant favorable inotropic activity of this new class of cardiotonic agents may represent an important pharmacologic approach to the future treatment of acute and chronic CHF. This briefreview summarizes the cardiotonic effects of calcium sensitizers, with particular emphasis on the hemodynamic actions of these drugs in various in vitro and in vivo heart preparations. We also attempt to draw conclusions for the therapeutic exploitation of these agents and delineate their possible role in the therapy of CHF.

AB - Over the last few years the development of calcium-sensitizing agents has led to a new approach to the treatment of congestive heart failure (CHF). These novel inotropic agents act directly on the contractile protein systems and correct the reduced responsiveness of the myofilaments to calcium. The resultant favorable inotropic activity of this new class of cardiotonic agents may represent an important pharmacologic approach to the future treatment of acute and chronic CHF. This briefreview summarizes the cardiotonic effects of calcium sensitizers, with particular emphasis on the hemodynamic actions of these drugs in various in vitro and in vivo heart preparations. We also attempt to draw conclusions for the therapeutic exploitation of these agents and delineate their possible role in the therapy of CHF.

KW - Calcium sensitizers

KW - Heart failure

KW - Hemodynamics

KW - Inotropic agents

KW - Systolic dysfunction

UR - http://www.scopus.com/inward/record.url?scp=0029558279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029558279&partnerID=8YFLogxK

M3 - Article

C2 - 8907128

AN - SCOPUS:0029558279

VL - 26

SP - S20-S31

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

ER -