Hemodynamic consequences of intravenously given E. coli suspension: Observations in a fulminant sepsis model in pigs, a descriptive case-control study

Mariann Berhés, N. Németh, Katalin Peto, Ádám Deák, Endre Hajdú, Ábel Molnár, Péter Árkosy, J. Szabó, B. Fülesdi

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Background: The aim of the present work was to assess systemic hemodynamic changes using PiCCo monitoring in a porcine model of E. coli-induced fulminant sepsis. Methods: Thirty-one healthy female Hungahib pigs were randomly assigned into control (n = 15) or septic groups (n = 16). In the sepsis group Escherichia coli culture was intravenously administrated in a continuously increasing manner according to the following protocol: 2 ml of bacterial culture suspended in physiological saline was injected in the first 30 min, then 4 ml of bacterial culture was administered within 30 min, followed by infusion of 32 ml bacterial culture for 2 h. Control animals received identical amount of saline infusion. Systemic hemodynamic parameters were assessed by PiCCo monitoring in both groups. Results: Resting hemodynamic parameters were identical in the two groups. In control animals, systemic hemodynamic variables were relatively stable during the entire procedure. In septic animals shock developed in 165 (IQR: 60-255) min after starting the injection of E. coli solution. Blood pressure values gradually decreased, whereas pulse rate increased. A decrease in cardiac index, an increased systemic vascular resistance, and a decreased stroke volume variation were observed. Conclusions: These results may serve as additional pathophysiological information of hemodynamic changes occurring during hypodynamic sepsis and may contribute to a better understanding of the pathomechanism of septic multiple organ failure.

Original languageEnglish
Article number11
JournalEuropean journal of medical research
Issue number1
Publication statusPublished - Feb 13 2019



  • E. coli
  • Experimental sepsis
  • PiCCo monitoring

ASJC Scopus subject areas

  • Medicine(all)

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