Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque

Caroline Cheng, Annemarie M. Noordeloos, V. Jeney, Miguel P. Soares, Frans Moll, Gerard Pasterkamp, Patrick W. Serruys, Henricus J. Duckers

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

BACKGROUND: The molecular regulation for the transition from stable to vulnerable plaque remains to be elucidated. Heme oxygenase 1 (HO-1) and its metabolites have been implicated in the cytoprotective defense against oxidative injury in atherogenesis. In this study, we sought to assess the role of HO-1 in the progression toward plaque instability in carotid artery disease in patients and in a murine model of vulnerable plaque development. METHODS AND RESULTS: Atherectomy biopsy from 112 patients with clinical carotid artery disease was collected and stratified according to characteristics of plaque vulnerability. HO-1 expression correlated closely with features of vulnerable human atheromatous plaque (P

Original languageEnglish
Pages (from-to)3017-3027
Number of pages11
JournalCirculation
Volume119
Issue number23
DOIs
Publication statusPublished - Jun 16 2009

Fingerprint

Heme Oxygenase-1
Carotid Artery Diseases
Atherectomy
Atherosclerotic Plaques
Atherosclerosis
Biopsy
Wounds and Injuries

Keywords

  • Atherosclerosis
  • Coronary disease
  • Genes
  • Inflammation
  • Vasculature

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Cheng, C., Noordeloos, A. M., Jeney, V., Soares, M. P., Moll, F., Pasterkamp, G., ... Duckers, H. J. (2009). Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque. Circulation, 119(23), 3017-3027. https://doi.org/10.1161/CIRCULATIONAHA.108.808618

Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque. / Cheng, Caroline; Noordeloos, Annemarie M.; Jeney, V.; Soares, Miguel P.; Moll, Frans; Pasterkamp, Gerard; Serruys, Patrick W.; Duckers, Henricus J.

In: Circulation, Vol. 119, No. 23, 16.06.2009, p. 3017-3027.

Research output: Contribution to journalArticle

Cheng, C, Noordeloos, AM, Jeney, V, Soares, MP, Moll, F, Pasterkamp, G, Serruys, PW & Duckers, HJ 2009, 'Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque', Circulation, vol. 119, no. 23, pp. 3017-3027. https://doi.org/10.1161/CIRCULATIONAHA.108.808618
Cheng, Caroline ; Noordeloos, Annemarie M. ; Jeney, V. ; Soares, Miguel P. ; Moll, Frans ; Pasterkamp, Gerard ; Serruys, Patrick W. ; Duckers, Henricus J. / Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque. In: Circulation. 2009 ; Vol. 119, No. 23. pp. 3017-3027.
@article{7c8a05cc29664a0d873355c3bb24015e,
title = "Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque",
abstract = "BACKGROUND: The molecular regulation for the transition from stable to vulnerable plaque remains to be elucidated. Heme oxygenase 1 (HO-1) and its metabolites have been implicated in the cytoprotective defense against oxidative injury in atherogenesis. In this study, we sought to assess the role of HO-1 in the progression toward plaque instability in carotid artery disease in patients and in a murine model of vulnerable plaque development. METHODS AND RESULTS: Atherectomy biopsy from 112 patients with clinical carotid artery disease was collected and stratified according to characteristics of plaque vulnerability. HO-1 expression correlated closely with features of vulnerable human atheromatous plaque (P",
keywords = "Atherosclerosis, Coronary disease, Genes, Inflammation, Vasculature",
author = "Caroline Cheng and Noordeloos, {Annemarie M.} and V. Jeney and Soares, {Miguel P.} and Frans Moll and Gerard Pasterkamp and Serruys, {Patrick W.} and Duckers, {Henricus J.}",
year = "2009",
month = "6",
day = "16",
doi = "10.1161/CIRCULATIONAHA.108.808618",
language = "English",
volume = "119",
pages = "3017--3027",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "23",

}

TY - JOUR

T1 - Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque

AU - Cheng, Caroline

AU - Noordeloos, Annemarie M.

AU - Jeney, V.

AU - Soares, Miguel P.

AU - Moll, Frans

AU - Pasterkamp, Gerard

AU - Serruys, Patrick W.

AU - Duckers, Henricus J.

PY - 2009/6/16

Y1 - 2009/6/16

N2 - BACKGROUND: The molecular regulation for the transition from stable to vulnerable plaque remains to be elucidated. Heme oxygenase 1 (HO-1) and its metabolites have been implicated in the cytoprotective defense against oxidative injury in atherogenesis. In this study, we sought to assess the role of HO-1 in the progression toward plaque instability in carotid artery disease in patients and in a murine model of vulnerable plaque development. METHODS AND RESULTS: Atherectomy biopsy from 112 patients with clinical carotid artery disease was collected and stratified according to characteristics of plaque vulnerability. HO-1 expression correlated closely with features of vulnerable human atheromatous plaque (P

AB - BACKGROUND: The molecular regulation for the transition from stable to vulnerable plaque remains to be elucidated. Heme oxygenase 1 (HO-1) and its metabolites have been implicated in the cytoprotective defense against oxidative injury in atherogenesis. In this study, we sought to assess the role of HO-1 in the progression toward plaque instability in carotid artery disease in patients and in a murine model of vulnerable plaque development. METHODS AND RESULTS: Atherectomy biopsy from 112 patients with clinical carotid artery disease was collected and stratified according to characteristics of plaque vulnerability. HO-1 expression correlated closely with features of vulnerable human atheromatous plaque (P

KW - Atherosclerosis

KW - Coronary disease

KW - Genes

KW - Inflammation

KW - Vasculature

UR - http://www.scopus.com/inward/record.url?scp=67649557000&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649557000&partnerID=8YFLogxK

U2 - 10.1161/CIRCULATIONAHA.108.808618

DO - 10.1161/CIRCULATIONAHA.108.808618

M3 - Article

VL - 119

SP - 3017

EP - 3027

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 23

ER -