Nowadays, HELLP syndrome (hemolysis, elevated liver enzymes, low platelet count) is one of the most severe complications in pregnancy. In 90% of cases HELLP syndrome is associated to preeclampsia, and it is present in almost 10% of severe preeclampsias. The early diagnosis is very important for the successful treatment. Clinical signs (epigastric pain/or pain in the right upper part of the abdomen, nausea, vomiting, flu-like symptoms, hypertension and proteinuria) and laboratory findings (elevated liver transaminase enzyme and lactate dehydrogenase levels, high bilirubin concentration, low platelet count) lead to the accurate diagnosis. Differential diagnosis includes thrombotic thrombocytopenic purpura, immune thrombocytopenic purpura, haemolytic uraemic syndrome, acute fatty liver of pregnancy. The recognition of HELLP syndrome indicates termination of pregnancy frequently by caesarean section. Patients with HELLP syndrome require intensive care and monitoring in the early postoperative period. In spite of the quick intervention maternal and fetal morbidity is significant. The most frequent maternal complications are disseminated intravascular coagulation, placental abruption, renal failure, and pulmonary edema. Knowledge on HELLP syndrome is very important for each physician managing pregnant women, because quick,early diagnosis can significantly improve the outcome of this severe disease.
|Number of pages||4|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Oct 3 1998|
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