Helicobacter pylori lipopolysaccharide provokes iNOS-mediated acute systemic microvascular inflammatory responses in rat cardiac, hepatic, renal and pulmonary tissues

Brendan J.R. Whittle, Éva Morschl, József Pozsár, Anthony P. Moran, Ferenc László

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We have examined the effects of intravenous administration of a purified lipopolysaccharide (LPS) from Helicobacter pylori (3 mg kg-1, i.v.) on rat vascular permeability, assessed by the radiolabelled human serum albumin leakage technique in the heart, kidney, liver and lung 4 h after challenge. An increased vascular permeability in cardiac, renal, hepatic and pulmonary tissues after challenge was determined. The albumin leakage observed in all these organs could be prevented by the selective inducible nitric oxide synthase inhibitor, N-(8-(aminomethyl)benzyl)-acetamidine (1400W; 0.2-1 mg kg-1, s.c.) administered concurrently with LPS. Thus, H. pylori LPS can provoke a microvascular inflammatory response in the rat cardiac, renal, hepatic and pulmonary tissues, actions mediated through the activation of the inducible nitric oxide synhase isoenzyme.

Original languageEnglish
Pages (from-to)257-259
Number of pages3
JournalJournal of Physiology Paris
Volume95
Issue number1-6
DOIs
Publication statusPublished - Nov 12 2001

Keywords

  • Heart
  • Helicobacter pylori endotoxin
  • Inducible nitric oxide synthase
  • Inflammation
  • Kidney
  • Liver
  • Lung

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

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