Helicobacter pylori infection in european children with gastro-duodenal ulcers and erosions

Patrick Bontems, Nicolas Kalach, Jean Vanderpas, Barbara Iwanczak, Thomas Casswall, Sibylle Koletzko, Giuseppina Oderda, Maria Jose Martinez-Gomez, Pedro Urruzuno, Angelika Kindermann, Josef Sykora, G. Verès, Eleftheria Roma-Giannikou, Ender Pehlivanoglu, Francis Megraud, Samy Cadranel

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: To analyze risk factors associated with gastro-duodenal ulcers and erosions in children. Methods: Open, prospective, multicenter, case-control study carried out in 11 European countries in patients with gastric or duodenal ulcers/erosions and 2 age-matched controls each. Possible risk factors were recorded. Logistic regression models were performed with adjustment for centers and age groups. Results: Seven-hundred thirty-two patients (244 cases, 153 with erosions only and 91 with ulcers, and 488 controls) were recruited. Children receiving antimicrobials or acid suppressive drugs before endoscopy were excluded (202 cases/390 controls remained for risk factor analysis). Helicobacter pylori was detected more frequently in cases than controls but only in 32.0% versus 20.1% in controls (P = 0.001). Independent exposure factors for gastric ulcers were male gender (P = 0.001), chronic neurologic disease (P = 0.015), chronic renal disease (P 0.001) and nonsteroidal anti-inflammatory drug consumption (P = 0.035). Exposure factors for duodenal ulcers were H. pylori infection (P 0.001) and steroid consumption (P = 0.031). Chronic renal disease was the only independent factor associated with gastric erosions (P = 0.026), those associated with duodenal erosions being H. pylori infection (P = 0.023), active smoking (P = 0.006) and chronic arthritis (P = 0.008). No risk factor was identified in 97/202 (48.0%) cases. Conclusions: H. pylori remains a risk factor for duodenal, but not for gastric lesions in children in countries with low prevalence of infection. No risk factor could be identified in half of the children with gastro-duodenal ulcers/erosions.

Original languageEnglish
Pages (from-to)1324-1329
Number of pages6
JournalPediatric Infectious Disease Journal
Volume32
Issue number12
DOIs
Publication statusPublished - 2013

Fingerprint

Helicobacter Infections
Duodenal Ulcer
Helicobacter pylori
Stomach Ulcer
Chronic Renal Insufficiency
Stomach
Logistic Models
Nervous System Diseases
Pharmaceutical Preparations
Endoscopy
Statistical Factor Analysis
Ulcer
Arthritis
Case-Control Studies
Chronic Disease
Anti-Inflammatory Agents
Age Groups
Smoking
Steroids
Acids

Keywords

  • Children
  • Gastric and duodenal erosions
  • Gastric and duodenal ulcer
  • Helicobacter pylori
  • Peptic ulcer disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases
  • Microbiology (medical)
  • Medicine(all)

Cite this

Bontems, P., Kalach, N., Vanderpas, J., Iwanczak, B., Casswall, T., Koletzko, S., ... Cadranel, S. (2013). Helicobacter pylori infection in european children with gastro-duodenal ulcers and erosions. Pediatric Infectious Disease Journal, 32(12), 1324-1329. https://doi.org/10.1097/INF.0000000000000005

Helicobacter pylori infection in european children with gastro-duodenal ulcers and erosions. / Bontems, Patrick; Kalach, Nicolas; Vanderpas, Jean; Iwanczak, Barbara; Casswall, Thomas; Koletzko, Sibylle; Oderda, Giuseppina; Martinez-Gomez, Maria Jose; Urruzuno, Pedro; Kindermann, Angelika; Sykora, Josef; Verès, G.; Roma-Giannikou, Eleftheria; Pehlivanoglu, Ender; Megraud, Francis; Cadranel, Samy.

In: Pediatric Infectious Disease Journal, Vol. 32, No. 12, 2013, p. 1324-1329.

Research output: Contribution to journalArticle

Bontems, P, Kalach, N, Vanderpas, J, Iwanczak, B, Casswall, T, Koletzko, S, Oderda, G, Martinez-Gomez, MJ, Urruzuno, P, Kindermann, A, Sykora, J, Verès, G, Roma-Giannikou, E, Pehlivanoglu, E, Megraud, F & Cadranel, S 2013, 'Helicobacter pylori infection in european children with gastro-duodenal ulcers and erosions', Pediatric Infectious Disease Journal, vol. 32, no. 12, pp. 1324-1329. https://doi.org/10.1097/INF.0000000000000005
Bontems, Patrick ; Kalach, Nicolas ; Vanderpas, Jean ; Iwanczak, Barbara ; Casswall, Thomas ; Koletzko, Sibylle ; Oderda, Giuseppina ; Martinez-Gomez, Maria Jose ; Urruzuno, Pedro ; Kindermann, Angelika ; Sykora, Josef ; Verès, G. ; Roma-Giannikou, Eleftheria ; Pehlivanoglu, Ender ; Megraud, Francis ; Cadranel, Samy. / Helicobacter pylori infection in european children with gastro-duodenal ulcers and erosions. In: Pediatric Infectious Disease Journal. 2013 ; Vol. 32, No. 12. pp. 1324-1329.
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AU - Bontems, Patrick

AU - Kalach, Nicolas

AU - Vanderpas, Jean

AU - Iwanczak, Barbara

AU - Casswall, Thomas

AU - Koletzko, Sibylle

AU - Oderda, Giuseppina

AU - Martinez-Gomez, Maria Jose

AU - Urruzuno, Pedro

AU - Kindermann, Angelika

AU - Sykora, Josef

AU - Verès, G.

AU - Roma-Giannikou, Eleftheria

AU - Pehlivanoglu, Ender

AU - Megraud, Francis

AU - Cadranel, Samy

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AB - Background: To analyze risk factors associated with gastro-duodenal ulcers and erosions in children. Methods: Open, prospective, multicenter, case-control study carried out in 11 European countries in patients with gastric or duodenal ulcers/erosions and 2 age-matched controls each. Possible risk factors were recorded. Logistic regression models were performed with adjustment for centers and age groups. Results: Seven-hundred thirty-two patients (244 cases, 153 with erosions only and 91 with ulcers, and 488 controls) were recruited. Children receiving antimicrobials or acid suppressive drugs before endoscopy were excluded (202 cases/390 controls remained for risk factor analysis). Helicobacter pylori was detected more frequently in cases than controls but only in 32.0% versus 20.1% in controls (P = 0.001). Independent exposure factors for gastric ulcers were male gender (P = 0.001), chronic neurologic disease (P = 0.015), chronic renal disease (P 0.001) and nonsteroidal anti-inflammatory drug consumption (P = 0.035). Exposure factors for duodenal ulcers were H. pylori infection (P 0.001) and steroid consumption (P = 0.031). Chronic renal disease was the only independent factor associated with gastric erosions (P = 0.026), those associated with duodenal erosions being H. pylori infection (P = 0.023), active smoking (P = 0.006) and chronic arthritis (P = 0.008). No risk factor was identified in 97/202 (48.0%) cases. Conclusions: H. pylori remains a risk factor for duodenal, but not for gastric lesions in children in countries with low prevalence of infection. No risk factor could be identified in half of the children with gastro-duodenal ulcers/erosions.

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