Heat shock response in photosynthetic organisms: Membrane and lipid connections

Ibolya Horváth, Attila Glatz, Hitoshi Nakamoto, Michael L. Mishkind, Teun Munnik, Yonousse Saidi, Pierre Goloubinoff, John L. Harwood, László Vigh

Research output: Contribution to journalReview article

86 Citations (Scopus)

Abstract

The ability of photosynthetic organisms to adapt to increases in environmental temperatures is becoming more important with climate change. Heat stress is known to induce heat-shock proteins (HSPs) many of which act as chaperones. Traditionally, it has been thought that protein denaturation acts as a trigger for HSP induction. However, increasing evidence has shown that many stress events cause HSP induction without commensurate protein denaturation. This has led to the membrane sensor hypothesis where the membrane's physical and structural properties play an initiating role in the heat shock response. In this review, we discuss heat-induced modulation of the membrane's physical state and changes to these properties which can be brought about by interaction with HSPs. Heat stress also leads to changes in lipid-based signaling cascades and alterations in calcium transport and availability. Such observations emphasize the importance of membranes and their lipids in the heat shock response and provide a new perspective for guiding further studies into the mechanisms that mediate cellular and organismal responses to heat stress.

Original languageEnglish
Pages (from-to)208-220
Number of pages13
JournalProgress in Lipid Research
Volume51
Issue number3
DOIs
Publication statusPublished - Jul 1 2012

Keywords

  • Heat shock response
  • Membrane fluidizer
  • Membrane sensor hypothesis
  • Molecular chaperones
  • Phosphatidic acid
  • Phosphatidylinositol 4,5-bisphosphate
  • Signaling lipids
  • Small heat shock proteins
  • Transient Ca influx

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Fingerprint Dive into the research topics of 'Heat shock response in photosynthetic organisms: Membrane and lipid connections'. Together they form a unique fingerprint.

  • Cite this