A hósokkfehérjék, mint az immunválasz dajkái. Eletünk és a szükséges stressz.

Translated title of the contribution: Heat shock proteins as chaperones of the immune response. The optimal stress of life

Research output: Contribution to journalArticle

Abstract

The author reviews the complex role of heat-shock proteins during the immune reaction, especially the cellular effects of heat-shock proteins during recognition processes by innate immunity. The pathogenetic role of heat-shock proteins in two multifactorial diseases, inflammatory bowel disease and atherosclerosis, is summarized. A new hypothesis is presented dealing with the "immunodeficiency burden" as the aggregate effect of the genetic polymorphisms resulting in disease susceptibility. According to this mechanism the aggregate effect of polymorphisms resulting in failure of protective immunity determines the susceptibility for the disease in the given subject, when a specific environmental factor is present.

Original languageHungarian
Pages (from-to)1331-1339
Number of pages9
JournalOrvosi Hetilap
Volume144
Issue number27
Publication statusPublished - Jul 6 2003

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Heat-Shock Proteins
Psychological Stress
Disease Susceptibility
Genetic Polymorphisms
Inflammatory Bowel Diseases
Innate Immunity
Immunity
Atherosclerosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A hósokkfehérjék, mint az immunválasz dajkái. Eletünk és a szükséges stressz. / Prohászka, Z.

In: Orvosi Hetilap, Vol. 144, No. 27, 06.07.2003, p. 1331-1339.

Research output: Contribution to journalArticle

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