Heat shock protein polymorphism predisposes to urinary tract malformations and renal transplantation in children

K. Rusai, N. F. Banki, A. Prokai, L. Podracka, B. Szebeni, T. Tulassay, G. Reusz, P. Sallay, R. Krmendy, A. J. Szabóo, A. Fekete

Research output: Contribution to journalArticle

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Abstract

Background: Anatomical malformations of the kidney and urinary tract account for 17% of pediatric renal transplantation procedures. Heat shock proteins (HSPs) are molecular chaperones with a protective function that promotes cell survival. HSP72 is an endogenous ligand for toll-like receptor TLR4, thereby stimulating innate immunity. Both in adults and children, decreased expression of HSP70s is associated with a number of kidney diseases. Objective: To assess the prevalence of HSPA1A G(190)C, HSPA1B A(1267)G, and TLR4 A(896)G polymorphisms in children who had undergone kidney transplantation. Patients and Methods: Genotypes were analyzed using allele-specific polymerase chain reaction in 41 pediatric recipients. Allelic prevalence was related to reference values in 65 age- and sex-matched healthy children. Results: Clinical data did not reveal a difference between any of the groups. HSPA1B (1267)GG genotype and HSPA1B (1267)G allele were observed more frequently in the transplant recipients compared with the control group: AA vs AG: odds ratio [OR], 12.6; 95% confidence interval [CI], 1.58100.0; P = .004; AA vs GG: OR, 20.80; 95% CI, 2.32187.00; P = .01; and A vs G: OR, 2.10; 95% CI, 1.193.07; P = .01. Furthermore, the prevalence of the HSPA1B (1267)GG genotype was greater in transplant recipients with vs without urinary tract malformations: AG vs GG: OR, 0.10; 95% CI, 0.090.48; P = .007. No differences were observed in the other studied polymorphisms. Conclusion: Our findings suggest an association between the carrier status of HSPA1B (1267)G with urinary tract malformations, leading to end-stage renal disease requiring kidney transplantation. This observation raises further questions about the clinical and therapeutic relevance of this polymorphism to pediatric nephrology.

Original languageEnglish
Pages (from-to)2309-2311
Number of pages3
JournalTransplantation Proceedings
Volume42
Issue number6
DOIs
Publication statusPublished - Jul 2010

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Heat-Shock Proteins
Urinary Tract
Kidney Transplantation
Odds Ratio
Confidence Intervals
Genotype
Pediatrics
Alleles
Molecular Chaperones
Nephrology
Toll-Like Receptors
Kidney Diseases
Innate Immunity
Chronic Kidney Failure
Cell Survival
Reference Values
Ligands
Kidney
Polymerase Chain Reaction
Control Groups

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Heat shock protein polymorphism predisposes to urinary tract malformations and renal transplantation in children. / Rusai, K.; Banki, N. F.; Prokai, A.; Podracka, L.; Szebeni, B.; Tulassay, T.; Reusz, G.; Sallay, P.; Krmendy, R.; Szabóo, A. J.; Fekete, A.

In: Transplantation Proceedings, Vol. 42, No. 6, 07.2010, p. 2309-2311.

Research output: Contribution to journalArticle

Rusai, K. ; Banki, N. F. ; Prokai, A. ; Podracka, L. ; Szebeni, B. ; Tulassay, T. ; Reusz, G. ; Sallay, P. ; Krmendy, R. ; Szabóo, A. J. ; Fekete, A. / Heat shock protein polymorphism predisposes to urinary tract malformations and renal transplantation in children. In: Transplantation Proceedings. 2010 ; Vol. 42, No. 6. pp. 2309-2311.
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abstract = "Background: Anatomical malformations of the kidney and urinary tract account for 17{\%} of pediatric renal transplantation procedures. Heat shock proteins (HSPs) are molecular chaperones with a protective function that promotes cell survival. HSP72 is an endogenous ligand for toll-like receptor TLR4, thereby stimulating innate immunity. Both in adults and children, decreased expression of HSP70s is associated with a number of kidney diseases. Objective: To assess the prevalence of HSPA1A G(190)C, HSPA1B A(1267)G, and TLR4 A(896)G polymorphisms in children who had undergone kidney transplantation. Patients and Methods: Genotypes were analyzed using allele-specific polymerase chain reaction in 41 pediatric recipients. Allelic prevalence was related to reference values in 65 age- and sex-matched healthy children. Results: Clinical data did not reveal a difference between any of the groups. HSPA1B (1267)GG genotype and HSPA1B (1267)G allele were observed more frequently in the transplant recipients compared with the control group: AA vs AG: odds ratio [OR], 12.6; 95{\%} confidence interval [CI], 1.58100.0; P = .004; AA vs GG: OR, 20.80; 95{\%} CI, 2.32187.00; P = .01; and A vs G: OR, 2.10; 95{\%} CI, 1.193.07; P = .01. Furthermore, the prevalence of the HSPA1B (1267)GG genotype was greater in transplant recipients with vs without urinary tract malformations: AG vs GG: OR, 0.10; 95{\%} CI, 0.090.48; P = .007. No differences were observed in the other studied polymorphisms. Conclusion: Our findings suggest an association between the carrier status of HSPA1B (1267)G with urinary tract malformations, leading to end-stage renal disease requiring kidney transplantation. This observation raises further questions about the clinical and therapeutic relevance of this polymorphism to pediatric nephrology.",
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AU - Rusai, K.

AU - Banki, N. F.

AU - Prokai, A.

AU - Podracka, L.

AU - Szebeni, B.

AU - Tulassay, T.

AU - Reusz, G.

AU - Sallay, P.

AU - Krmendy, R.

AU - Szabóo, A. J.

AU - Fekete, A.

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N2 - Background: Anatomical malformations of the kidney and urinary tract account for 17% of pediatric renal transplantation procedures. Heat shock proteins (HSPs) are molecular chaperones with a protective function that promotes cell survival. HSP72 is an endogenous ligand for toll-like receptor TLR4, thereby stimulating innate immunity. Both in adults and children, decreased expression of HSP70s is associated with a number of kidney diseases. Objective: To assess the prevalence of HSPA1A G(190)C, HSPA1B A(1267)G, and TLR4 A(896)G polymorphisms in children who had undergone kidney transplantation. Patients and Methods: Genotypes were analyzed using allele-specific polymerase chain reaction in 41 pediatric recipients. Allelic prevalence was related to reference values in 65 age- and sex-matched healthy children. Results: Clinical data did not reveal a difference between any of the groups. HSPA1B (1267)GG genotype and HSPA1B (1267)G allele were observed more frequently in the transplant recipients compared with the control group: AA vs AG: odds ratio [OR], 12.6; 95% confidence interval [CI], 1.58100.0; P = .004; AA vs GG: OR, 20.80; 95% CI, 2.32187.00; P = .01; and A vs G: OR, 2.10; 95% CI, 1.193.07; P = .01. Furthermore, the prevalence of the HSPA1B (1267)GG genotype was greater in transplant recipients with vs without urinary tract malformations: AG vs GG: OR, 0.10; 95% CI, 0.090.48; P = .007. No differences were observed in the other studied polymorphisms. Conclusion: Our findings suggest an association between the carrier status of HSPA1B (1267)G with urinary tract malformations, leading to end-stage renal disease requiring kidney transplantation. This observation raises further questions about the clinical and therapeutic relevance of this polymorphism to pediatric nephrology.

AB - Background: Anatomical malformations of the kidney and urinary tract account for 17% of pediatric renal transplantation procedures. Heat shock proteins (HSPs) are molecular chaperones with a protective function that promotes cell survival. HSP72 is an endogenous ligand for toll-like receptor TLR4, thereby stimulating innate immunity. Both in adults and children, decreased expression of HSP70s is associated with a number of kidney diseases. Objective: To assess the prevalence of HSPA1A G(190)C, HSPA1B A(1267)G, and TLR4 A(896)G polymorphisms in children who had undergone kidney transplantation. Patients and Methods: Genotypes were analyzed using allele-specific polymerase chain reaction in 41 pediatric recipients. Allelic prevalence was related to reference values in 65 age- and sex-matched healthy children. Results: Clinical data did not reveal a difference between any of the groups. HSPA1B (1267)GG genotype and HSPA1B (1267)G allele were observed more frequently in the transplant recipients compared with the control group: AA vs AG: odds ratio [OR], 12.6; 95% confidence interval [CI], 1.58100.0; P = .004; AA vs GG: OR, 20.80; 95% CI, 2.32187.00; P = .01; and A vs G: OR, 2.10; 95% CI, 1.193.07; P = .01. Furthermore, the prevalence of the HSPA1B (1267)GG genotype was greater in transplant recipients with vs without urinary tract malformations: AG vs GG: OR, 0.10; 95% CI, 0.090.48; P = .007. No differences were observed in the other studied polymorphisms. Conclusion: Our findings suggest an association between the carrier status of HSPA1B (1267)G with urinary tract malformations, leading to end-stage renal disease requiring kidney transplantation. This observation raises further questions about the clinical and therapeutic relevance of this polymorphism to pediatric nephrology.

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