Heart rate variability after complete autonomic blockade in man

Gabor Jokkel, Istvan Bonyhay, M. Kollai

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

In a number of studies, using the autoregressive model for frequency domain analysis of R-R interval fluctuations, the low frequency (LF) component (centered at about 0.1 Hz) is claimed to index sympathetic activity level. The aim of this study was to investigate the mediation mechanism of the LF component by pharmacological blockade. Our results support earlier findings, obtained with the use of fast Fourier transformation, that in supine subjects spectral components of R-R interval variability at around 0.1 Hz are mediated mainly by cholinergic mechanisms. Therefore, the use of the LF component as sympathetic index appears questionable.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalJournal of the Autonomic Nervous System
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 20 1995

Fingerprint

Cholinergic Agents
Heart Rate
Pharmacology

Keywords

  • Atropine
  • Propranolol
  • RR interval
  • Spectral analysis

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Heart rate variability after complete autonomic blockade in man. / Jokkel, Gabor; Bonyhay, Istvan; Kollai, M.

In: Journal of the Autonomic Nervous System, Vol. 51, No. 1, 20.01.1995, p. 85-89.

Research output: Contribution to journalArticle

@article{8611aaa59f98479897ec01c922bbc9a2,
title = "Heart rate variability after complete autonomic blockade in man",
abstract = "In a number of studies, using the autoregressive model for frequency domain analysis of R-R interval fluctuations, the low frequency (LF) component (centered at about 0.1 Hz) is claimed to index sympathetic activity level. The aim of this study was to investigate the mediation mechanism of the LF component by pharmacological blockade. Our results support earlier findings, obtained with the use of fast Fourier transformation, that in supine subjects spectral components of R-R interval variability at around 0.1 Hz are mediated mainly by cholinergic mechanisms. Therefore, the use of the LF component as sympathetic index appears questionable.",
keywords = "Atropine, Propranolol, RR interval, Spectral analysis",
author = "Gabor Jokkel and Istvan Bonyhay and M. Kollai",
year = "1995",
month = "1",
day = "20",
doi = "10.1016/0165-1838(95)80010-8",
language = "English",
volume = "51",
pages = "85--89",
journal = "Autonomic Neuroscience: Basic and Clinical",
issn = "1566-0702",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Heart rate variability after complete autonomic blockade in man

AU - Jokkel, Gabor

AU - Bonyhay, Istvan

AU - Kollai, M.

PY - 1995/1/20

Y1 - 1995/1/20

N2 - In a number of studies, using the autoregressive model for frequency domain analysis of R-R interval fluctuations, the low frequency (LF) component (centered at about 0.1 Hz) is claimed to index sympathetic activity level. The aim of this study was to investigate the mediation mechanism of the LF component by pharmacological blockade. Our results support earlier findings, obtained with the use of fast Fourier transformation, that in supine subjects spectral components of R-R interval variability at around 0.1 Hz are mediated mainly by cholinergic mechanisms. Therefore, the use of the LF component as sympathetic index appears questionable.

AB - In a number of studies, using the autoregressive model for frequency domain analysis of R-R interval fluctuations, the low frequency (LF) component (centered at about 0.1 Hz) is claimed to index sympathetic activity level. The aim of this study was to investigate the mediation mechanism of the LF component by pharmacological blockade. Our results support earlier findings, obtained with the use of fast Fourier transformation, that in supine subjects spectral components of R-R interval variability at around 0.1 Hz are mediated mainly by cholinergic mechanisms. Therefore, the use of the LF component as sympathetic index appears questionable.

KW - Atropine

KW - Propranolol

KW - RR interval

KW - Spectral analysis

UR - http://www.scopus.com/inward/record.url?scp=0028819464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028819464&partnerID=8YFLogxK

U2 - 10.1016/0165-1838(95)80010-8

DO - 10.1016/0165-1838(95)80010-8

M3 - Article

C2 - 7722219

AN - SCOPUS:0028819464

VL - 51

SP - 85

EP - 89

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

SN - 1566-0702

IS - 1

ER -