Heart rate variability after complete autonomic blockade in man

Gabor Jokkel, Istvan Bonyhay, Mark Kollai

Research output: Contribution to journalArticle

62 Citations (Scopus)


In a number of studies, using the autoregressive model for frequency domain analysis of R-R interval fluctuations, the low frequency (LF) component (centered at about 0.1 Hz) is claimed to index sympathetic activity level. The aim of this study was to investigate the mediation mechanism of the LF component by pharmacological blockade. Our results support earlier findings, obtained with the use of fast Fourier transformation, that in supine subjects spectral components of R-R interval variability at around 0.1 Hz are mediated mainly by cholinergic mechanisms. Therefore, the use of the LF component as sympathetic index appears questionable.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalJournal of the Autonomic Nervous System
Issue number1
Publication statusPublished - Jan 20 1995



  • Atropine
  • Propranolol
  • RR interval
  • Spectral analysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology

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