Heart rate recovery after exercise is associated with renal function in patients with a homogenous chronic renal disease

István Kési, Balázs Sági, Tibor Vas, Tibor Kovács, István Wittmann, Judit Nagy

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Abstract

Background. Attenuated heart rate recovery (HRR) is an independent predictor of cardiac and total mortality. Diminished renal function is a similar predictor. There are no data concerning the interaction between the two risk factors. We studied HRR in patients with a homogeneous renal disease, IgA nephropathy.Methods. One hundred and seven patients with biopsy-proven chronic IgA nephropathy (71 males, 36 females aged 45 ± 11 years) performed a graded exercise treadmill stress test. HRR was measured as the heart rate difference between the peak value and the heart rate 1 min after exercise. The patients were divided into three groups based on estimated glomerular filtration rate (eGFR): CKD 1, eGFR ≥ 90 mlmin (n = 46); CKD 2, eGFR 60-89 mlmin (n = 38), CKD 3-4, eGFR 15-59 mlmin (n = 23). We compared these data with 29 normal controls (aged 46 ± 14 years).Results. HRR values corresponded to eGFR as follows: 29.9 ± 8.8 bpm normal controls, 27.8 ± 9.2 bpm CKD 1, 24.5 ± 10.5 bpm CKD 2 and 16.3 ± 9.3 bpm CKD 3-4. The latter differed from the other groups significantly (P < 0.05). Metabolic syndrome was common in IgA nephropathy patients (27). Metabolic syndrome patients had a HRR of 19.6 ± 10.1 bpm, compared to 25.8 ± 10.4 bpm in patients without metabolic syndrome (P = 0.007). Nevertheless, a multivariate regression analysis accepted only eGFR as an independent predictor of HRR.Conclusion. eGFR predicts HRR in patients with a homogenous renal disease. Metabolic syndrome influences HRR, albeit not independently in this cohort.

Original languageEnglish
Pages (from-to)509-513
Number of pages5
JournalNephrology Dialysis Transplantation
Volume25
Issue number2
DOIs
Publication statusPublished - Feb 1 2010

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Keywords

  • Cardiovascular risk
  • Chronic kidney disease
  • Heart rate recovery
  • IgA nephropathy
  • Metabolic syndrome

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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