Hearing disturbances in hypertrophic cardiomyopathy. Is the sensorineural disorder neurogenic or myogenic?

Miklós Csanády, Ferenc Tóth, Márta Hõgye, Andrea Vass, Róbert Sepp, M. Csanády, J. Czigner, József G. Kiss, J. Jóri, T. Forster

Research output: Contribution to journalArticle

Abstract

Background: In a previous study, we demonstrated that a hidden hearing defect is present in about 50% of patients with hypertrophic cardiomyopathy (HCM). Such defects were found significantly less frequently in age and clinical stage-matched patients with dilated cardiomyopathy (DCM), and were practically absent in patients with valvular aortic stenosis, and in patients taking β-receptor blockers for different reasons (such as hypertension, ischemic heart disease, etc.). The hearing disturbances were first examined by means of brain-stem evoked response audiometry (BAEP). This method permitted only a rough differentiation between the origins of cochlear (myogenic) and retrocochlear (neurogenic) hearing disturbances, and did not allow us to establish their myogenic or neurogenic nature with certainty. Aims: Our present aim was to determine whether the hearing disturbances present in HCM and DCM patients are myogenic or neurogenic in origin. Methods: The neurogenic function of the inner ear was examined by BAEP as before, and the myogenic function by the distortion product otoacoustic emission technique. Results: Myogenic abnormalities were found in 39/69 ears (57%) and neurogenic abnormalities in 19/69 (28%) ears among the HCM cases, as compared with 14/39 (36%) and 8/39 (21%) ears respectively among the DCM cases (p <0.005). Healthy controls displayed the lowest incidence of both types of hearing abnormalities. Conclusion: Our results lead us to conclude that myogenic lesions are more frequent than neurogenic lesions in patients with HCM. Both myogenic and neurogenic lesions are more frequent in HCM patients than in DCM patients or healthy controls. It may be hypothesized that abnormal sarcomeric proteins present in the muscular structures of the inner ear in HCM are possibly responsible for the hearing disorders in these patients, and that this is not merely a neurological defect.

Original languageEnglish
Pages (from-to)53-56
Number of pages4
JournalInternational Journal of Cardiology
Volume116
Issue number1
DOIs
Publication statusPublished - Mar 2 2007

Fingerprint

Hypertrophic Cardiomyopathy
Hearing
Dilated Cardiomyopathy
Ear
Inner Ear
Evoked Response Audiometry
Hearing Disorders
Cochlea
Aortic Valve Stenosis
Brain Stem
Myocardial Ischemia
Hypertension
Incidence

Keywords

  • Cochlea
  • Deaf-mutism
  • Hypertrophic cardiomyopathy
  • Sarcomere

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hearing disturbances in hypertrophic cardiomyopathy. Is the sensorineural disorder neurogenic or myogenic? / Csanády, Miklós; Tóth, Ferenc; Hõgye, Márta; Vass, Andrea; Sepp, Róbert; Csanády, M.; Czigner, J.; Kiss, József G.; Jóri, J.; Forster, T.

In: International Journal of Cardiology, Vol. 116, No. 1, 02.03.2007, p. 53-56.

Research output: Contribution to journalArticle

Csanády, Miklós ; Tóth, Ferenc ; Hõgye, Márta ; Vass, Andrea ; Sepp, Róbert ; Csanády, M. ; Czigner, J. ; Kiss, József G. ; Jóri, J. ; Forster, T. / Hearing disturbances in hypertrophic cardiomyopathy. Is the sensorineural disorder neurogenic or myogenic?. In: International Journal of Cardiology. 2007 ; Vol. 116, No. 1. pp. 53-56.
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abstract = "Background: In a previous study, we demonstrated that a hidden hearing defect is present in about 50{\%} of patients with hypertrophic cardiomyopathy (HCM). Such defects were found significantly less frequently in age and clinical stage-matched patients with dilated cardiomyopathy (DCM), and were practically absent in patients with valvular aortic stenosis, and in patients taking β-receptor blockers for different reasons (such as hypertension, ischemic heart disease, etc.). The hearing disturbances were first examined by means of brain-stem evoked response audiometry (BAEP). This method permitted only a rough differentiation between the origins of cochlear (myogenic) and retrocochlear (neurogenic) hearing disturbances, and did not allow us to establish their myogenic or neurogenic nature with certainty. Aims: Our present aim was to determine whether the hearing disturbances present in HCM and DCM patients are myogenic or neurogenic in origin. Methods: The neurogenic function of the inner ear was examined by BAEP as before, and the myogenic function by the distortion product otoacoustic emission technique. Results: Myogenic abnormalities were found in 39/69 ears (57{\%}) and neurogenic abnormalities in 19/69 (28{\%}) ears among the HCM cases, as compared with 14/39 (36{\%}) and 8/39 (21{\%}) ears respectively among the DCM cases (p <0.005). Healthy controls displayed the lowest incidence of both types of hearing abnormalities. Conclusion: Our results lead us to conclude that myogenic lesions are more frequent than neurogenic lesions in patients with HCM. Both myogenic and neurogenic lesions are more frequent in HCM patients than in DCM patients or healthy controls. It may be hypothesized that abnormal sarcomeric proteins present in the muscular structures of the inner ear in HCM are possibly responsible for the hearing disorders in these patients, and that this is not merely a neurological defect.",
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AU - Tóth, Ferenc

AU - Hõgye, Márta

AU - Vass, Andrea

AU - Sepp, Róbert

AU - Csanády, M.

AU - Czigner, J.

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AU - Jóri, J.

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AB - Background: In a previous study, we demonstrated that a hidden hearing defect is present in about 50% of patients with hypertrophic cardiomyopathy (HCM). Such defects were found significantly less frequently in age and clinical stage-matched patients with dilated cardiomyopathy (DCM), and were practically absent in patients with valvular aortic stenosis, and in patients taking β-receptor blockers for different reasons (such as hypertension, ischemic heart disease, etc.). The hearing disturbances were first examined by means of brain-stem evoked response audiometry (BAEP). This method permitted only a rough differentiation between the origins of cochlear (myogenic) and retrocochlear (neurogenic) hearing disturbances, and did not allow us to establish their myogenic or neurogenic nature with certainty. Aims: Our present aim was to determine whether the hearing disturbances present in HCM and DCM patients are myogenic or neurogenic in origin. Methods: The neurogenic function of the inner ear was examined by BAEP as before, and the myogenic function by the distortion product otoacoustic emission technique. Results: Myogenic abnormalities were found in 39/69 ears (57%) and neurogenic abnormalities in 19/69 (28%) ears among the HCM cases, as compared with 14/39 (36%) and 8/39 (21%) ears respectively among the DCM cases (p <0.005). Healthy controls displayed the lowest incidence of both types of hearing abnormalities. Conclusion: Our results lead us to conclude that myogenic lesions are more frequent than neurogenic lesions in patients with HCM. Both myogenic and neurogenic lesions are more frequent in HCM patients than in DCM patients or healthy controls. It may be hypothesized that abnormal sarcomeric proteins present in the muscular structures of the inner ear in HCM are possibly responsible for the hearing disorders in these patients, and that this is not merely a neurological defect.

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