HCMV Envelope Antigens Induce Both Humoral and Cellular Immunity in Guinea Pigs

Toru Furukawa, Eva Gonczol, Stuart Starr, Mark D. Tolpin, Alan Arbeter, Stanley A. Plotkin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Antibody and cellular immunity were measured in guinea pigs immunized with whole virion, with nucleocapsids of human cytomegalovirus or with solubilized antigens containing virus envelope proteins. All the three types of immunogens induced the production of humoral antibody as well as cytomegalovirus (CMV)-specific cellular immunity. In immunization experiments envelope antigen was as effective as immunization with whole virion.

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalProceedings of the Society for Experimental Biology and Medicine
Volume175
Issue number2
DOIs
Publication statusPublished - Feb 1984

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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