Has prostacyclin a mediating role upon the vasodilative effect of sodium nitroprusside?

B. Székács, E. Mohacsi, B. Gachalyi

Research output: Contribution to journalArticle

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Abstract

The possibility that prostacyclin has a mediating effect in the vasodilatory action of sodium nitroprusside was investigated in hypertensive patients (n = 45) using a sodium nitroprusside (Nipride Roche) infusion, at a rate sufficient to cause a 15% reduction in diastolic blood pressure for 5 hours after a control period of 150 min. In the collected urine the level of 6-keto-PGF(1α) was determined by radioimmunoassay. The urinary 6-keto-PGF(1α) excretion rate did not change significantly during the infusion, while the average dose/minute of Nipride infusion showed a linear, direct correlation with the urinary 6-keto-PGF(1α) excretion rate. The excretion rate of 6-keto-PGF(1α) in the urine was not correlated with the decrease in blood pressure during infusion of Nipride. The fact that during infusion of Nipride the urinary excretion rate of PGI2 metabolite correlated significantly with the dose of Nipride used for blood pressure reduction leads to the conclusion that sodium nitroprusside may release in loco vasodilator PGI2 from the vessels, and the amount of PGI2 with this origin is the major part in the actual renal PGI2 production.

Original languageEnglish
Pages (from-to)49-50
Number of pages2
JournalIRCS Medical Science
Volume14
Issue number1
Publication statusPublished - 1986

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Nitroprusside
Epoprostenol
Prostaglandins F
Blood pressure
Blood Pressure
Urine
Metabolites
Vasodilator Agents
Radioimmunoassay
Kidney

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Has prostacyclin a mediating role upon the vasodilative effect of sodium nitroprusside? / Székács, B.; Mohacsi, E.; Gachalyi, B.

In: IRCS Medical Science, Vol. 14, No. 1, 1986, p. 49-50.

Research output: Contribution to journalArticle

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