Harnessing the Versatility of Continuous-Flow Processes: Selective and Efficient Reactions

I. Mándity, Sándor B. Ötvös, György Szőlősi, F. Fülöp

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

There is a great need for effective transformations and a broad range of novel chemical entities. Continuous-flow (CF) approaches are of considerable current interest: highly efficient and selective reactions can be performed in CF reactors. The reaction setup of CF reactors offers a wide variety of possible points where versatility can be introduced. This article presents a number of selective and highly efficient gas–liquid–solid and liquid–solid reactions involving a range of reagents and immobilized catalysts. Enantioselective transformations through catalytic hydrogenation and organocatalytic reactions are included, and isotopically labelled compounds and pharmaceutically relevant 1,2,3-triazoles are synthesized in CF reactors. Importantly, the catalyst bed can be changed to a solid-phase peptide synthesis resin, with which peptide synthesis can be performed with the utilization of only 1.5 equivalents of the amino acid. (Figure presented.).

Original languageEnglish
Pages (from-to)1018-1033
Number of pages16
JournalChemical Record
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • catalysis
  • continuous-flow
  • reactors
  • selectivity
  • versatility

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry
  • Biochemistry
  • Biochemistry, medical

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