Haptoglobin polymorphisms are associated with Crohn's disease, disease behavior, and extraintestinal manifestations in hungarian patients

M. Papp, P. Lakatos, K. Palatka, Ildiko Foldi, M. Udvardy, J. Hársfalvi, Istvan Tornai, Zsuzsanna Vitalis, Tamas Dinya, A. Kovács, T. Molnár, P. Demeter, J. Papp, L. Lakatos, I. Altorjay, P. Fuszek, Henrik Csaba Horvath, P. Vargha, S. Fischer, J. OsztovitsL. Bene, F. Nagy, J. Lonovics, Levente Balint, Ferenc Huoranszky, Istvan Dobo, Z. Tulassay, L. Herszényi, P. Miheller, A. Németh, Gyorgy Szekely, Z. Erdélyi, G. Mester, Csaba Molnar, T. Pandúr

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17 Citations (Scopus)

Abstract

Functional differences and association with inflammatory disorders were found relating to three major haptoglobin (Hp) phenotypes. Our aim was to investigate Hp polymorphisms in Hungarian patients with Crohn's disease (CD). Four hundred sixty-eight CD patients and 384 healthy controls were examined. Hp phenotypes were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting of the sera. The frequency of the Hp 1 allele was significantly higher in CD (0.395; OR, 1.24; 95% CI, 1.02-1.52; P=0.03) compared to controls (0.345). In CD, Hp phenotype was associated with disease behavior (OR [Hp2-1 vs other], 2.06; 95% CI, 1.29-3.28 for inflammatory behavior). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in the Hp 2-2 compared to the Hp 1-1 phenotype (6.5% vs. 0.0%; P=0.039). We conclude that the Hp polymorphism is associated with CD, inflammatory disease behavior, and primary sclerosing cholangitis in Hungarian patients. Further studies are required to evaluate the significance of Hp polymorphisms in other populations from geographically diverse regions.

Original languageEnglish
Pages (from-to)1279-1284
Number of pages6
JournalDigestive Diseases and Sciences
Volume52
Issue number5
DOIs
Publication statusPublished - May 2007

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Haptoglobins
Crohn Disease
Phenotype
Sclerosing Cholangitis
Immunoblotting
Sodium Dodecyl Sulfate
Polyacrylamide Gel Electrophoresis
Alleles

Keywords

  • Crohn's disease
  • Disease behavior
  • Haptoglobin polymorphism
  • Primary sclerosing cholangitis
  • Th1/Th2 orientation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

@article{8d4f7a4bf7a642f893fb6f4e7beccbec,
title = "Haptoglobin polymorphisms are associated with Crohn's disease, disease behavior, and extraintestinal manifestations in hungarian patients",
abstract = "Functional differences and association with inflammatory disorders were found relating to three major haptoglobin (Hp) phenotypes. Our aim was to investigate Hp polymorphisms in Hungarian patients with Crohn's disease (CD). Four hundred sixty-eight CD patients and 384 healthy controls were examined. Hp phenotypes were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting of the sera. The frequency of the Hp 1 allele was significantly higher in CD (0.395; OR, 1.24; 95{\%} CI, 1.02-1.52; P=0.03) compared to controls (0.345). In CD, Hp phenotype was associated with disease behavior (OR [Hp2-1 vs other], 2.06; 95{\%} CI, 1.29-3.28 for inflammatory behavior). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in the Hp 2-2 compared to the Hp 1-1 phenotype (6.5{\%} vs. 0.0{\%}; P=0.039). We conclude that the Hp polymorphism is associated with CD, inflammatory disease behavior, and primary sclerosing cholangitis in Hungarian patients. Further studies are required to evaluate the significance of Hp polymorphisms in other populations from geographically diverse regions.",
keywords = "Crohn's disease, Disease behavior, Haptoglobin polymorphism, Primary sclerosing cholangitis, Th1/Th2 orientation",
author = "M. Papp and P. Lakatos and K. Palatka and Ildiko Foldi and M. Udvardy and J. H{\'a}rsfalvi and Istvan Tornai and Zsuzsanna Vitalis and Tamas Dinya and A. Kov{\'a}cs and T. Moln{\'a}r and P. Demeter and J. Papp and L. Lakatos and I. Altorjay and P. Fuszek and Horvath, {Henrik Csaba} and P. Vargha and S. Fischer and J. Osztovits and L. Bene and F. Nagy and J. Lonovics and Levente Balint and Ferenc Huoranszky and Istvan Dobo and Z. Tulassay and L. Hersz{\'e}nyi and P. Miheller and A. N{\'e}meth and Gyorgy Szekely and Z. Erd{\'e}lyi and G. Mester and Csaba Molnar and T. Pand{\'u}r",
year = "2007",
month = "5",
doi = "10.1007/s10620-006-9615-1",
language = "English",
volume = "52",
pages = "1279--1284",
journal = "Digestive Diseases and Sciences",
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TY - JOUR

T1 - Haptoglobin polymorphisms are associated with Crohn's disease, disease behavior, and extraintestinal manifestations in hungarian patients

AU - Papp, M.

AU - Lakatos, P.

AU - Palatka, K.

AU - Foldi, Ildiko

AU - Udvardy, M.

AU - Hársfalvi, J.

AU - Tornai, Istvan

AU - Vitalis, Zsuzsanna

AU - Dinya, Tamas

AU - Kovács, A.

AU - Molnár, T.

AU - Demeter, P.

AU - Papp, J.

AU - Lakatos, L.

AU - Altorjay, I.

AU - Fuszek, P.

AU - Horvath, Henrik Csaba

AU - Vargha, P.

AU - Fischer, S.

AU - Osztovits, J.

AU - Bene, L.

AU - Nagy, F.

AU - Lonovics, J.

AU - Balint, Levente

AU - Huoranszky, Ferenc

AU - Dobo, Istvan

AU - Tulassay, Z.

AU - Herszényi, L.

AU - Miheller, P.

AU - Németh, A.

AU - Szekely, Gyorgy

AU - Erdélyi, Z.

AU - Mester, G.

AU - Molnar, Csaba

AU - Pandúr, T.

PY - 2007/5

Y1 - 2007/5

N2 - Functional differences and association with inflammatory disorders were found relating to three major haptoglobin (Hp) phenotypes. Our aim was to investigate Hp polymorphisms in Hungarian patients with Crohn's disease (CD). Four hundred sixty-eight CD patients and 384 healthy controls were examined. Hp phenotypes were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting of the sera. The frequency of the Hp 1 allele was significantly higher in CD (0.395; OR, 1.24; 95% CI, 1.02-1.52; P=0.03) compared to controls (0.345). In CD, Hp phenotype was associated with disease behavior (OR [Hp2-1 vs other], 2.06; 95% CI, 1.29-3.28 for inflammatory behavior). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in the Hp 2-2 compared to the Hp 1-1 phenotype (6.5% vs. 0.0%; P=0.039). We conclude that the Hp polymorphism is associated with CD, inflammatory disease behavior, and primary sclerosing cholangitis in Hungarian patients. Further studies are required to evaluate the significance of Hp polymorphisms in other populations from geographically diverse regions.

AB - Functional differences and association with inflammatory disorders were found relating to three major haptoglobin (Hp) phenotypes. Our aim was to investigate Hp polymorphisms in Hungarian patients with Crohn's disease (CD). Four hundred sixty-eight CD patients and 384 healthy controls were examined. Hp phenotypes were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting of the sera. The frequency of the Hp 1 allele was significantly higher in CD (0.395; OR, 1.24; 95% CI, 1.02-1.52; P=0.03) compared to controls (0.345). In CD, Hp phenotype was associated with disease behavior (OR [Hp2-1 vs other], 2.06; 95% CI, 1.29-3.28 for inflammatory behavior). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in the Hp 2-2 compared to the Hp 1-1 phenotype (6.5% vs. 0.0%; P=0.039). We conclude that the Hp polymorphism is associated with CD, inflammatory disease behavior, and primary sclerosing cholangitis in Hungarian patients. Further studies are required to evaluate the significance of Hp polymorphisms in other populations from geographically diverse regions.

KW - Crohn's disease

KW - Disease behavior

KW - Haptoglobin polymorphism

KW - Primary sclerosing cholangitis

KW - Th1/Th2 orientation

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