Haplotyping by capillary electrophoresis

Eszter Szantai, Zsolt Ronai, Agnes Szilagyi, Maria Sasvari-Szekely, András Guttman

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

The investigation of the genetic background and phenotype structures of complex diseases, such as cardiovascular or psychiatric disorders and tumors, is one of the most scrutinized fields of the post genomic era. Besides the multiplex analysis of genetic markers and polymorphisms throughout the whole genome, more and more attention is focused on the interaction between the etiological factors of these traits. Haplotype determination, rather than multiplex genotyping seems to be one of the first building blocks of this endeavor. This review focuses on the importance and theoretical background of haplotyping, and summarizes the recent examples of novel and emerging haplotyping techniques by capillary gel electrophoresis based DNA fragment analysis, a powerful tool for the examination of the inheritance of complex traits.

Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalJournal of Chromatography A
Volume1079
Issue number1-2 SPEC. ISS.
DOIs
Publication statusPublished - Jun 24 2005

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Keywords

  • Capillary electrophoresis
  • Genotype
  • Haplotype
  • Polymorphism
  • SNP

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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