Haplotyping by capillary electrophoresis

Eszter Szantai, Z. Rónai, Agnes Szilagyi, M. Sasvári, A. Guttman

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The investigation of the genetic background and phenotype structures of complex diseases, such as cardiovascular or psychiatric disorders and tumors, is one of the most scrutinized fields of the post genomic era. Besides the multiplex analysis of genetic markers and polymorphisms throughout the whole genome, more and more attention is focused on the interaction between the etiological factors of these traits. Haplotype determination, rather than multiplex genotyping seems to be one of the first building blocks of this endeavor. This review focuses on the importance and theoretical background of haplotyping, and summarizes the recent examples of novel and emerging haplotyping techniques by capillary gel electrophoresis based DNA fragment analysis, a powerful tool for the examination of the inheritance of complex traits.

Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalJournal of Chromatography A
Volume1079
Issue number1-2 SPEC. ISS.
DOIs
Publication statusPublished - Jun 24 2005

Fingerprint

Capillary electrophoresis
Capillary Electrophoresis
Genetic Polymorphisms
Electrophoresis
Polymorphism
Genetic Markers
Haplotypes
Psychiatry
Tumors
Genes
Gels
Genome
Phenotype
DNA
Neoplasms
Genetic Background

Keywords

  • Capillary electrophoresis
  • Genotype
  • Haplotype
  • Polymorphism
  • SNP

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Haplotyping by capillary electrophoresis. / Szantai, Eszter; Rónai, Z.; Szilagyi, Agnes; Sasvári, M.; Guttman, A.

In: Journal of Chromatography A, Vol. 1079, No. 1-2 SPEC. ISS., 24.06.2005, p. 41-49.

Research output: Contribution to journalArticle

Szantai, Eszter ; Rónai, Z. ; Szilagyi, Agnes ; Sasvári, M. ; Guttman, A. / Haplotyping by capillary electrophoresis. In: Journal of Chromatography A. 2005 ; Vol. 1079, No. 1-2 SPEC. ISS. pp. 41-49.
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