Haplotype analysis of the apolipoprotein A5 gene in patients with the metabolic syndrome

P. Kisfali, M. Mohás, A. Maász, N. Polgár, F. Hadarits, L. Markó, P. Brasnyó, K. Horvatovich, T. Oroszlán, Z. Bagosi, Z. Bujtor, B. Gasztonyi, J. Rinfel, I. Wittmann, B. Melegh

Research output: Contribution to journalArticle

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Abstract

Background and aims: In recent studies, the T-1131C variant of apolipoprotein A5 (APOA5) gene was found to confer a risk for metabolic syndrome (MS). Here we determined four haplotype-tagging polymorphisms (T-1131C, IVS3+. G476A, T1259C, and C56G), and studied the distribution of the naturally occurring major haplotype profiles in MS. Methods and results: A total of 343 MS patients and 284 controls were genotyped using PCR-RFLP methods. Both in MS and control groups, we confirmed the already known association of -. 1131C, IVS3+. 473A and 1259C minor alleles with elevated triglyceride levels. The prevalence of the APOA5*2 haplotype (the combination of T-1131C, IVS3+. G476A and T1259C SNPs) was 13.1% in MS patients, and 4.9% in controls (p

Original languageEnglish
Pages (from-to)505-511
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume20
Issue number7
DOIs
Publication statusPublished - Sep 2010

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Apolipoproteins
Haplotypes
Genes
Metabolome
Restriction Fragment Length Polymorphisms
Single Nucleotide Polymorphism
Triglycerides
Alleles
Polymerase Chain Reaction
Control Groups

Keywords

  • Apolipoprotein A5
  • Haplotypes
  • Metabolic syndrome
  • Serum triglycerides

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Haplotype analysis of the apolipoprotein A5 gene in patients with the metabolic syndrome. / Kisfali, P.; Mohás, M.; Maász, A.; Polgár, N.; Hadarits, F.; Markó, L.; Brasnyó, P.; Horvatovich, K.; Oroszlán, T.; Bagosi, Z.; Bujtor, Z.; Gasztonyi, B.; Rinfel, J.; Wittmann, I.; Melegh, B.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 20, No. 7, 09.2010, p. 505-511.

Research output: Contribution to journalArticle

Kisfali, P. ; Mohás, M. ; Maász, A. ; Polgár, N. ; Hadarits, F. ; Markó, L. ; Brasnyó, P. ; Horvatovich, K. ; Oroszlán, T. ; Bagosi, Z. ; Bujtor, Z. ; Gasztonyi, B. ; Rinfel, J. ; Wittmann, I. ; Melegh, B. / Haplotype analysis of the apolipoprotein A5 gene in patients with the metabolic syndrome. In: Nutrition, Metabolism and Cardiovascular Diseases. 2010 ; Vol. 20, No. 7. pp. 505-511.
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