Hallmarks of gastrointestinal neuroendocrine tumours: Implications for treatment

Annemiek Walenkamp, Guillermo Crespo, Felipe Fierro Maya, Reidar Fossmark, Peter Igaz, Anja Rinke, Gianluca Tamagno, Giovanni Vitale, Kjell Öberg, Tim Meyer

Research output: Contribution to journalReview article

29 Citations (Scopus)


In the past few years, there have been advances in the treatment of neuroendocrine tumours (NETs) and improvements in our understanding of NET biology. However, the benefits to patients have been relatively modest and much remains yet to be done. The 'Hallmarks of Cancer', as defined by Hanahan and Weinberg, provide a conceptual framework for understanding the aberrations that underlie tumourigenesis and to help identify potential targets for therapy. In this study, our objective is to review the major molecular characteristics of NETs, based on the recently modified 'Hallmarks of Cancer', and highlight areas that require further research.

Original languageEnglish
Pages (from-to)R44-R460
JournalEndocrine-Related Cancer
Issue number6
Publication statusPublished - Dec 1 2014



  • Cancer
  • Neuroendocrine tumours
  • Treatment
  • Tumourigenesis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research

Cite this

Walenkamp, A., Crespo, G., Maya, F. F., Fossmark, R., Igaz, P., Rinke, A., Tamagno, G., Vitale, G., Öberg, K., & Meyer, T. (2014). Hallmarks of gastrointestinal neuroendocrine tumours: Implications for treatment. Endocrine-Related Cancer, 21(6), R44-R460. https://doi.org/10.1530/ERC-14-0106