A hemoglobinszint ciklicitása renalis anaemiában - A CERA és a hagyományos erythropoesisstimuláló szerek összehasonlítása

Translated title of the contribution: Haemoglobin cyclicity in renal anaemia

G. Reusz, Szabó J. Attila

Research output: Contribution to journalArticle

Abstract

Erythropoiesis stimulating agents are glycoproteins in which the oligosaccharide chains that terminate in sialic acid bind to the peptide with glycosidic bond. The lower the sialic acid content of the erythropoietin, the higher its receptor affinity, while its half-life in the circulation decreases. The biological effect depends on the balance of these factors. In the third-generation erythropoiesis stimulating molecule CERA (continuous erythropoietin receptor activator) a large polyethylene glycol molecule is substituted for sialic acid to ensure slow elimination and better biological efficiency. During treatment with erythropoiesis stimulating agents, haemoglobin levels show cyclic fluctuation. This cyclicity is undesirable, so its frequency and amplitude should be reduced as much as possible. The most recent results suggest that CERA may reduce haemoglobin cyclicity.

Original languageHungarian
Pages (from-to)767-774
Number of pages8
JournalLege Artis Medicinae
Volume17
Issue number11
Publication statusPublished - Nov 2007

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N-Acetylneuraminic Acid
Periodicity
Hematinics
Anemia
Hemoglobins
Kidney
Erythropoiesis
Erythropoietin
Oligosaccharides
Half-Life
Glycoproteins
Peptides
continuous erythropoietin receptor activator

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A hemoglobinszint ciklicitása renalis anaemiában - A CERA és a hagyományos erythropoesisstimuláló szerek összehasonlítása. / Reusz, G.; Attila, Szabó J.

In: Lege Artis Medicinae, Vol. 17, No. 11, 11.2007, p. 767-774.

Research output: Contribution to journalArticle

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