Haemodynamic and coronary effects of quazodine in cats with developing myocardial infarcts

J. R. PARRATT, EILEEN WINSLOW

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4 Citations (Scopus)

Abstract

Acute ligation of the descending branch of the left coronary artery in anaesthetized cats resulted, within 1–2 h, in a 30% decrease in local blood flow in the region mainly supplied by the ligated vessel, a fall in systemic blood pressure, in cardiac output, and in left ventricular dP/dt max (LVdP/dt). There was electrocardiographic evidence of myocardial ischaemia (pronounced ST elevation). In these animals with developing myocardial infarcts, intravenous infusions of quazodine (MJ1988; 6,7‐dimethoxy‐4‐ethyl‐quinazoline) markedly increased myocardial contractility and local myocardial blood flow in the developing infarct, and decreased systemic arterial pressure, peripheral vascular resistance and left ventricular end‐diastolic pressure, effects similar to those observed in normal cats. The increase in cardiac contractility (cardiac output and LVdP/dt) occurred without a concomitant increase in myocardial metabolic heat production. This ‘oxygen sparing effect’ probably results from a decrease in left ventricular wall tension. It is suggested that quazodine warrants further investigation as a cardiac stimulant in power failure following myocardial infarction in man. 1972 Royal Pharmaceutical Society of Great Britain

Original languageEnglish
Pages (from-to)673-680
Number of pages8
JournalJournal of Pharmacy and Pharmacology
Volume24
Issue number9
DOIs
Publication statusPublished - Sep 1972

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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