H1 tau haplotype-related genomic variation at 17q21.3 as an Asian heritage of the European Gypsy population

P. Z. Álmos, S. Horváth, Á Czibula, I. Raskó, B. Sipos, P. Bihari, J. Béres, A. Juhász, Z. Janka, J. Kálmán

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this study, we examine the frequency of a 900 kb inversion at 17q21.3 in the Gypsy and Caucasian populations of Hungary, which may reflect the Asian origin of Gypsy populations. Of the two haplotypes (H1 and H2), H2 is thought to be exclusively of Caucasian origin, and its occurrence in other racial groups is likely to reflect admixture. In our sample, the H1 haplotype was significantly more frequent in the Gypsy population (89.8 vs 75.5%, P<0.001) and was in Hardy-Weinberg disequilibrium (P=0.017). The 17q21.3 region includes the gene of microtubule-associated protein tau, and this result might imply higher sensitivity to H1 haplotype-related multifactorial tauopathies among Gypsies.

Original languageEnglish
Pages (from-to)416-419
Number of pages4
JournalHeredity
Volume101
Issue number5
DOIs
Publication statusPublished - Nov 1 2008

Keywords

  • Genomic variation
  • Gypsy
  • Roma
  • Tau haplotype
  • Tauopathies

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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