H1 histamine receptor antagonist inhibits constitutive growth of Jurkat T cells and antigen-specific proliferation of ovalbumin-specific murine T cells

Zsuzsa Radvány, Zsuzsa Darvas, Krisztina Kerekes, József Prechl, Csaba Szalai, Eva Pállinger, Lászlo Valéria, Valéria Lia Varga, Matyas Sandor, Anna Erdei, András Falus

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. We examined the expression of HDC and the effect of histamine receptor antagonists on the proliferation of a human T cell line, Jurkat and on antigen-driven proliferation of lymphocytes from ovalbumin-immunized mice. Our results demonstrate that HDC is inducible in Jurkat cells by anti-CD3. The H1 receptor antagonist triprolidine dose dependently inhibits proliferation of both Jurkat cells and ovalbumin-stimulated murine lymphocytes, while the H2 antagonist ranitidine was ineffective. Alpha-fluoro-methyl-histidine blocking HDC activity did not inhibit the T cell proliferation, suggesting an existing pool of histamine in T cells.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalSeminars in Cancer Biology
Volume10
Issue number1
DOIs
Publication statusPublished - Feb 2000

Keywords

  • H1 receptor
  • HDC
  • Histamine
  • Proliferation
  • T cell

ASJC Scopus subject areas

  • Cancer Research

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