Guts and gall

Bile acids in regulation of intestinal epithelial function in health and disease

P. Hegyi, Jozsef Maléth, Julian R. Walters, Alan F. Hofmann, Stephen J. Keely

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and fluid to and from the luminal contents. At the same time, epithelial cells are responsible for forming a physical and biochemical barrier that prevents the entry into the body of harmful agents, such as bacteria and their toxins. Dysregulation of epithelial transport and barrier function is associated with the pathogenesis of a number of conditions throughout the intestine, such as inflammatory bowel disease, chronic diarrhea, pancreatitis, reflux esophagitis, and cancer. Driven by discovery of specific receptors on intestinal epithelial cells, new insights into mechanisms that control their synthesis and enterohepatic circulation, and a growing appreciation of their roles as bioactive bacterial metabolites, bile acids are currently receiving a great deal of interest as critical regulators of epithelial function in health and disease. This review aims to summarize recent advances in this field and to highlight how bile acids are now emerging as exciting new targets for disease intervention.

Original languageEnglish
Pages (from-to)1983-2023
Number of pages41
JournalPhysiological Reviews
Volume98
Issue number4
DOIs
Publication statusPublished - Oct 1 2018

Fingerprint

Bile Acids and Salts
Epithelial Cells
Health
Enterohepatic Circulation
Peptic Esophagitis
Architectural Accessibility
Chronic Pancreatitis
Inflammatory Bowel Diseases
Electrolytes
Intestines
Gastrointestinal Tract
Diarrhea
Bacteria
Cell Line
Food
Enzymes
Neoplasms

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Physiology (medical)

Cite this

Guts and gall : Bile acids in regulation of intestinal epithelial function in health and disease. / Hegyi, P.; Maléth, Jozsef; Walters, Julian R.; Hofmann, Alan F.; Keely, Stephen J.

In: Physiological Reviews, Vol. 98, No. 4, 01.10.2018, p. 1983-2023.

Research output: Contribution to journalReview article

Hegyi, P. ; Maléth, Jozsef ; Walters, Julian R. ; Hofmann, Alan F. ; Keely, Stephen J. / Guts and gall : Bile acids in regulation of intestinal epithelial function in health and disease. In: Physiological Reviews. 2018 ; Vol. 98, No. 4. pp. 1983-2023.
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