Guinea pigs immunized with xenogeneic cells: Skin test, in vitro stimulation; cytotoxicity of lymph node cells

GyözöG G. Petrányi, Eva Klein, Erik Svedmyr, Hans Jacobsson

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Guinea pigs were immunized with cells of a human lymphoblastoid line. While nonsensitized lymph node cells were not influenced, those derived from immunized animals were markedly stimulated in vitro by the human cells. Maximal activity was found with lymphocytes harvested on day 6. The response was paralleled with the strength of skin induration elicited by the human cells and with the efficiency of the cytotoxic effect of lymphocytes on human target cells. The stimulation and cytotoxicity was specific while the skin test demonstrated cross reactivity with mouse cells.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalCellular Immunology
Issue number1
Publication statusPublished - Oct 1973


ASJC Scopus subject areas

  • Immunology

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