Guidance of cell migration by the Drosophila PDGF/VEGF receptor

Peter Duchek, K. Somogyi, Gáspár Jékely, Simone Beccari, Pernille Rorth

Research output: Contribution to journalArticle

328 Citations (Scopus)

Abstract

Directed cell migrations are important for development, but the signaling pathways and mechanisms responsible for guiding cell migration in vivo are poorly understood. Migration of border cells during Drosophila oogenesis is a simple and attractive model system in which to address these questions. We demonstrate that PVR, a receptor tyrosine kinase related to mammalian PDGF and VEGF receptors, acts in border cells to guide them to the oocyte. The oocyte is the source of a ligand for PVR, PDGF/VEGF factor 1 (PVF1). Intriguingly, the guidance function of PVR is largely redundant with that of EGFR. We present evidence implicating Rac and the Rac activator Mbc/DOCK180/CED-5 as mediators of the guidance signal.

Original languageEnglish
Pages (from-to)17-26
Number of pages10
JournalCell
Volume107
Issue number1
DOIs
Publication statusPublished - Oct 5 2001

Fingerprint

Platelet-Derived Growth Factor Receptors
Vascular Endothelial Growth Factor Receptor
Receptor Protein-Tyrosine Kinases
Vascular Endothelial Growth Factor A
Cell Movement
Ligands
Oocytes
Oogenesis
Drosophila
Drosophila Pvr protein

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Guidance of cell migration by the Drosophila PDGF/VEGF receptor. / Duchek, Peter; Somogyi, K.; Jékely, Gáspár; Beccari, Simone; Rorth, Pernille.

In: Cell, Vol. 107, No. 1, 05.10.2001, p. 17-26.

Research output: Contribution to journalArticle

Duchek, P, Somogyi, K, Jékely, G, Beccari, S & Rorth, P 2001, 'Guidance of cell migration by the Drosophila PDGF/VEGF receptor', Cell, vol. 107, no. 1, pp. 17-26. https://doi.org/10.1016/S0092-8674(01)00502-5
Duchek, Peter ; Somogyi, K. ; Jékely, Gáspár ; Beccari, Simone ; Rorth, Pernille. / Guidance of cell migration by the Drosophila PDGF/VEGF receptor. In: Cell. 2001 ; Vol. 107, No. 1. pp. 17-26.
@article{c79c8fedaa6b4d08973096b466e7aaff,
title = "Guidance of cell migration by the Drosophila PDGF/VEGF receptor",
abstract = "Directed cell migrations are important for development, but the signaling pathways and mechanisms responsible for guiding cell migration in vivo are poorly understood. Migration of border cells during Drosophila oogenesis is a simple and attractive model system in which to address these questions. We demonstrate that PVR, a receptor tyrosine kinase related to mammalian PDGF and VEGF receptors, acts in border cells to guide them to the oocyte. The oocyte is the source of a ligand for PVR, PDGF/VEGF factor 1 (PVF1). Intriguingly, the guidance function of PVR is largely redundant with that of EGFR. We present evidence implicating Rac and the Rac activator Mbc/DOCK180/CED-5 as mediators of the guidance signal.",
author = "Peter Duchek and K. Somogyi and G{\'a}sp{\'a}r J{\'e}kely and Simone Beccari and Pernille Rorth",
year = "2001",
month = "10",
day = "5",
doi = "10.1016/S0092-8674(01)00502-5",
language = "English",
volume = "107",
pages = "17--26",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - Guidance of cell migration by the Drosophila PDGF/VEGF receptor

AU - Duchek, Peter

AU - Somogyi, K.

AU - Jékely, Gáspár

AU - Beccari, Simone

AU - Rorth, Pernille

PY - 2001/10/5

Y1 - 2001/10/5

N2 - Directed cell migrations are important for development, but the signaling pathways and mechanisms responsible for guiding cell migration in vivo are poorly understood. Migration of border cells during Drosophila oogenesis is a simple and attractive model system in which to address these questions. We demonstrate that PVR, a receptor tyrosine kinase related to mammalian PDGF and VEGF receptors, acts in border cells to guide them to the oocyte. The oocyte is the source of a ligand for PVR, PDGF/VEGF factor 1 (PVF1). Intriguingly, the guidance function of PVR is largely redundant with that of EGFR. We present evidence implicating Rac and the Rac activator Mbc/DOCK180/CED-5 as mediators of the guidance signal.

AB - Directed cell migrations are important for development, but the signaling pathways and mechanisms responsible for guiding cell migration in vivo are poorly understood. Migration of border cells during Drosophila oogenesis is a simple and attractive model system in which to address these questions. We demonstrate that PVR, a receptor tyrosine kinase related to mammalian PDGF and VEGF receptors, acts in border cells to guide them to the oocyte. The oocyte is the source of a ligand for PVR, PDGF/VEGF factor 1 (PVF1). Intriguingly, the guidance function of PVR is largely redundant with that of EGFR. We present evidence implicating Rac and the Rac activator Mbc/DOCK180/CED-5 as mediators of the guidance signal.

UR - http://www.scopus.com/inward/record.url?scp=0035812719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035812719&partnerID=8YFLogxK

U2 - 10.1016/S0092-8674(01)00502-5

DO - 10.1016/S0092-8674(01)00502-5

M3 - Article

C2 - 11595182

AN - SCOPUS:0035812719

VL - 107

SP - 17

EP - 26

JO - Cell

JF - Cell

SN - 0092-8674

IS - 1

ER -