Guidance of cell migration by the Drosophila PDGF/VEGF receptor

Peter Duchek, Kálmán Somogyi, Gáspár Jékely, Simone Beccari, Pernille Rorth

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330 Citations (Scopus)

Abstract

Directed cell migrations are important for development, but the signaling pathways and mechanisms responsible for guiding cell migration in vivo are poorly understood. Migration of border cells during Drosophila oogenesis is a simple and attractive model system in which to address these questions. We demonstrate that PVR, a receptor tyrosine kinase related to mammalian PDGF and VEGF receptors, acts in border cells to guide them to the oocyte. The oocyte is the source of a ligand for PVR, PDGF/VEGF factor 1 (PVF1). Intriguingly, the guidance function of PVR is largely redundant with that of EGFR. We present evidence implicating Rac and the Rac activator Mbc/DOCK180/CED-5 as mediators of the guidance signal.

Original languageEnglish
Pages (from-to)17-26
Number of pages10
JournalCell
Volume107
Issue number1
DOIs
Publication statusPublished - Oct 5 2001

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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