Growth of human colorectal tumor xenografts in immunosuppressed mice reconstituted with normal cells

L. Kópper, T. Van Hanh, C. Hegedus, K. Lapis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The growth of human colorectal tumor xenograft lines was studied in immunosuppressed mice after reconstitution with sensitized and nonsensitized macrophages, thymocytes and splenocytes obtained from normal mice. Intravenously injected macrophages caused temporary inhibition of tumor growth. This effect needed intact cells and was independent from the presence of the spleen. The weight of spleen increased in normal mice sensitized with xenograft tumor, and the sensitized splenocytes injected into tumor-bearing immunosuppressed mice caused substantial tumor-growth delay.

Original languageEnglish
Pages (from-to)141-147
Number of pages7
JournalExperimental Cell Biology
Volume49
Issue number3
Publication statusPublished - 1981

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Heterografts
Colorectal Neoplasms
Growth
Neoplasms
Spleen
Macrophages
Thymocytes
Weights and Measures

ASJC Scopus subject areas

  • Cell Biology

Cite this

Growth of human colorectal tumor xenografts in immunosuppressed mice reconstituted with normal cells. / Kópper, L.; Van Hanh, T.; Hegedus, C.; Lapis, K.

In: Experimental Cell Biology, Vol. 49, No. 3, 1981, p. 141-147.

Research output: Contribution to journalArticle

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