Growth hormone secretion of the neonatal rat pituitaries is stimulated by gamma-aminobutyric acid in vitro

Zsuzsanna Ács, Gábor B. Makara, Ervin Stark

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Growth hormone secretion from pituitaries of neonatal rats was stimulated by gamma-aminobutyric acid (GABA) and the GABA agonist muscimol in vitro. This response to GABA was absent after the 9th postnatal day. The stimulation of growth hormone secretion by GABA was antagonized by bicuculline-methiodide and by picrotoxin. Diazepam stimulated while baclophen had no effect on growth hormone secretion. This stimulatory GABA effect might be related to a certain developmental stage of the pituitary GABA receptors or to the lack of hypothalamic regulatory influence(s) in the newborn.

Original languageEnglish
Pages (from-to)1505-1511
Number of pages7
JournalLife Sciences
Volume34
Issue number16
DOIs
Publication statusPublished - Apr 16 1984

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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