Growth hormone-releasing factor (GRF)-like immunoreactivity in sensory ganglia of the rat

Rita Józsa, Horst W. Korf, Istvan Merchenthaler

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Growth hormone-releasing factor (GRF)-like immunoreactivity has been demonstrated in the trigeminal and spinal ganglia of fetal, young and adult rats by use of peroxidase-antiperoxidase immunohistochemistry. GRF-like-immunoreactive cells first appear during the second half of embryonic life, as early as day 17. In untreated animals the GRF-immunoreactive elements form approximately 1% of all ganglion cells in the trigeminal and spinal ganglia; their numbers do not change significantly during development. The granular immunoreaction product is confined to perikarya, especially to the perinuclear region. Nerve fibers displaying GRF-like immunoreactivity were found neither in the ganglia, nor in the corresponding central and peripheral areas of termination. The possible role of GRF in sensory ganglia is discussed.

Original languageEnglish
Pages (from-to)441-444
Number of pages4
JournalCell And Tissue Research
Volume247
Issue number2
DOIs
Publication statusPublished - Jan 1 1987

Keywords

  • Development, ontogenetic
  • Growth hormone-releasing factor (GRF)
  • Neuropeptide immunocytochemistry
  • Rat
  • Spinal ganglion
  • Trigeminal ganglion

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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