Growth hormone inhibits the interleukin-6 induced junB protooncogene and fibrinogen expression in HepG2 human hepatoma cells

P. Igaz, Beáta Dérfalvi, Sára Tóth, A. Falus

Research output: Contribution to journalArticle

Abstract

Growth hormone (GH) and interleukin-6 (IL-6) play important regulatory roles in multiple endocrinological and immunological functions. In this study we examined whether GH can modulate the actions of IL-6. In HepG2 human hepatoma cells we studied the effects of different GH concentrations on the expression of the junB mRNA as an early and on the biosynthesis of fibrinogen protein as a late model of IL-6-related hepatic response. Both GH and IL-6 alone induced the expression of junB and fibrinogen but GH significantly inhibited the actions of higher (10 and 20 ng/ml) IL-6 concentrations in a dose dependent manner. These findings further underline the importance of interplay between the effectiveness of IL-6 and GH in various physiological processes.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalActa biologica Hungarica
Volume49
Issue number1
Publication statusPublished - Dec 1 1998

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Keywords

  • Fibrinogen
  • Growth hormone
  • Interleukin-6
  • JunB mRNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

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