7 colorectal tumors were transplanted to immunosuppressed mice. The biological characteristics, the growth rate, and histology of the two takes during the course of serial transplantations are described. The sensitivity to chemotherapeutic substances was studied: the treatment with 5-fluorouracil and methyl-CCNU resulted in complete remission; following treatment with dianhydrogalactitol a temporary growth inhibition could be observed. The authors have found the xenotransplanted human tumors a useful system for the preclinical trial of cytostatic substances in these tumors; they are similar in many aspects to those growing in humans.
|Number of pages||9|
|Publication status||Published - Jan 1 1978|
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