Griseochelin, a novel carboxylic acid antibiotic from Streptomyces griseus

U. Gräfe, W. Schade, M. Roth, L. Radics, M. Incze, K. Újszászy

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Griseochelin, C33H60O7, isolated from an asporogenous strain of Streptomyces griseus represents a novel carboxylic acid antibiotic. The metabolite, which is active against Gram-positive bacteria, forms water-insoluble salts with mono- and divalent cations and binds alkaline-earth metal ions specifically in 2:1 (X2M) stoichiometry. Detailed spectral (IR, MS and NMR) studies provide full characterization of its constitution featuring a carboxylic acid function, a substituted tetrahydropyran ring, an allylic OH group which are accomodated within a tetrahydroxylated-octamethyl-C25 diene backbone.

Original languageEnglish
Pages (from-to)836-846
Number of pages11
JournalJournal of Antibiotics
Volume37
Issue number8
Publication statusPublished - 1984

Fingerprint

Streptomyces griseus
Carboxylic Acids
Alkaline Earth Metals
Anti-Bacterial Agents
Monovalent Cations
Constitution and Bylaws
Divalent Cations
Gram-Positive Bacteria
Salts
Ions
Water
zincophorin

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Gräfe, U., Schade, W., Roth, M., Radics, L., Incze, M., & Újszászy, K. (1984). Griseochelin, a novel carboxylic acid antibiotic from Streptomyces griseus. Journal of Antibiotics, 37(8), 836-846.

Griseochelin, a novel carboxylic acid antibiotic from Streptomyces griseus. / Gräfe, U.; Schade, W.; Roth, M.; Radics, L.; Incze, M.; Újszászy, K.

In: Journal of Antibiotics, Vol. 37, No. 8, 1984, p. 836-846.

Research output: Contribution to journalArticle

Gräfe, U, Schade, W, Roth, M, Radics, L, Incze, M & Újszászy, K 1984, 'Griseochelin, a novel carboxylic acid antibiotic from Streptomyces griseus', Journal of Antibiotics, vol. 37, no. 8, pp. 836-846.
Gräfe, U. ; Schade, W. ; Roth, M. ; Radics, L. ; Incze, M. ; Újszászy, K. / Griseochelin, a novel carboxylic acid antibiotic from Streptomyces griseus. In: Journal of Antibiotics. 1984 ; Vol. 37, No. 8. pp. 836-846.
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