Green tea and vitamin C ameliorate some neuro-functional and biochemical signs of arsenic toxicity in rats

Kitti Sárközi, A. Papp, Edina Horváth, Zsuzsanna Máté, Ágnes Ferencz, E. Hermesz, Judit Krisch, Edit Paulik, A. Szabó

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background/objectives: Nervous system damage is one of the consequences of oral exposure to waterborne inorganic arsenic. In this work, the role of oxidative status in the neurotoxicity of arsenic and the possible role of two foodborne antioxidants in ameliorating arsenic-related oxidative stress were investigated. Methods: Male Wistar rats were given 10 mg/kg b.w. of trivalent inorganic arsenic (in the form of NaAsO2), 5 day/week for 6 weeks by gavage, combined with vitamin C solution (1 g/l) or green tea infusion (2.5 g in 500 ml boiled water) as antioxidants given in the drinking fluid. Results: Body weight gain was reduced by arsenic from the second week and the antioxidants had no effect on that. Cortical evoked potentials had increased latency, tail nerve conduction velocity was reduced, and this latter effect was counteracted by the antioxidants. The effect of green tea was stronger than that of vitamin C, and green tea also diminished lipid peroxidation induced by As. There was fair correlation between brain As levels, electrophysiological changes, and lipid peroxidation, suggesting a causal relationship. Discussion: Natural antioxidants might be useful in the protection of the central nervous system against the toxicity of oral As.

Original languageEnglish
Pages (from-to)102-109
Number of pages8
JournalNutritional Neuroscience
Volume19
Issue number3
DOIs
Publication statusPublished - 2016

Fingerprint

Arsenic
Tea
Ascorbic Acid
Antioxidants
Lipid Peroxidation
Neural Conduction
Evoked Potentials
Nervous System
Drinking
Weight Gain
Tail
Wistar Rats
Oxidative Stress
Central Nervous System
Body Weight
Water
Brain

Keywords

  • Antioxidant
  • Arsenic
  • Evoked electrical activity
  • Neurotoxicity
  • Oxidative stress
  • Rat

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Neuroscience(all)

Cite this

Green tea and vitamin C ameliorate some neuro-functional and biochemical signs of arsenic toxicity in rats. / Sárközi, Kitti; Papp, A.; Horváth, Edina; Máté, Zsuzsanna; Ferencz, Ágnes; Hermesz, E.; Krisch, Judit; Paulik, Edit; Szabó, A.

In: Nutritional Neuroscience, Vol. 19, No. 3, 2016, p. 102-109.

Research output: Contribution to journalArticle

Sárközi, Kitti ; Papp, A. ; Horváth, Edina ; Máté, Zsuzsanna ; Ferencz, Ágnes ; Hermesz, E. ; Krisch, Judit ; Paulik, Edit ; Szabó, A. / Green tea and vitamin C ameliorate some neuro-functional and biochemical signs of arsenic toxicity in rats. In: Nutritional Neuroscience. 2016 ; Vol. 19, No. 3. pp. 102-109.
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