Grb2-associated binder 1 (Gab1) adaptor/scaffolding protein regulates Erk signal in human B cells

Adrienn Angyal, David Medgyesi, G. Sármay

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

RNA silencing experiments showed that knocking down Gab1 adaptor protein in BL41 human Burkitt lymphoma cells significantly reduced B cell receptor (BCR)-induced Erk phosphorylation, indicating that Gab1 plays a pivotal role in regulating Erk activity in B cells.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages326-331
Number of pages6
Volume1090
DOIs
Publication statusPublished - Dec 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1090
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Binders
B-Lymphocytes
Cells
Phosphorylation
Burkitt Lymphoma
RNA Interference
Proteins
RNA
Experiments

Keywords

  • B cell
  • Gab
  • RNA silencing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Angyal, A., Medgyesi, D., & Sármay, G. (2006). Grb2-associated binder 1 (Gab1) adaptor/scaffolding protein regulates Erk signal in human B cells. In Annals of the New York Academy of Sciences (Vol. 1090, pp. 326-331). (Annals of the New York Academy of Sciences; Vol. 1090). https://doi.org/10.1196/annals.1378.036

Grb2-associated binder 1 (Gab1) adaptor/scaffolding protein regulates Erk signal in human B cells. / Angyal, Adrienn; Medgyesi, David; Sármay, G.

Annals of the New York Academy of Sciences. Vol. 1090 2006. p. 326-331 (Annals of the New York Academy of Sciences; Vol. 1090).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Angyal, A, Medgyesi, D & Sármay, G 2006, Grb2-associated binder 1 (Gab1) adaptor/scaffolding protein regulates Erk signal in human B cells. in Annals of the New York Academy of Sciences. vol. 1090, Annals of the New York Academy of Sciences, vol. 1090, pp. 326-331. https://doi.org/10.1196/annals.1378.036
Angyal A, Medgyesi D, Sármay G. Grb2-associated binder 1 (Gab1) adaptor/scaffolding protein regulates Erk signal in human B cells. In Annals of the New York Academy of Sciences. Vol. 1090. 2006. p. 326-331. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1378.036
Angyal, Adrienn ; Medgyesi, David ; Sármay, G. / Grb2-associated binder 1 (Gab1) adaptor/scaffolding protein regulates Erk signal in human B cells. Annals of the New York Academy of Sciences. Vol. 1090 2006. pp. 326-331 (Annals of the New York Academy of Sciences).
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