Gray Matter Is Targeted in First-Attack Multiple Sclerosis

Steven E. Schutzer, Thomas E. Angel, Tao Liu, Athena A. Schepmoes, Fang Xie, Jonas Bergquist, L. Vécsei, Denes Zadori, David G. Camp, Bart K. Holland, Richard D. Smith, Patricia K. Coyle

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The cause of multiple sclerosis (MS), its driving pathogenesis at the earliest stages, and what factors allow the first clinical attack to manifest remain unknown. Some imaging studies suggest gray rather than white matter may be involved early, and some postulate this may be predictive of developing MS. Other imaging studies are in conflict. To determine if there was objective molecular evidence of gray matter involvement in early MS we used high-resolution mass spectrometry to identify proteins in the cerebrospinal fluid (CSF) of first-attack MS patients (two independent groups) compared to established relapsing remitting (RR) MS and controls. We found that the CSF proteins in first-attack patients were differentially enriched for gray matter components (axon, neuron, synapse). Myelin components did not distinguish these groups. The results support that gray matter dysfunction is involved early in MS, and also may be integral for the initial clinical presentation.

Original languageEnglish
Article numbere66117
JournalPLoS One
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 10 2013

Fingerprint

sclerosis
Multiple Sclerosis
Cerebrospinal fluid
Cerebrospinal Fluid Proteins
Imaging techniques
Neurons
Mass spectrometry
cerebrospinal fluid
Relapsing-Remitting Multiple Sclerosis
image analysis
Myelin Sheath
Proteins
myelin sheath
Synapses
Axons
synapse
Mass Spectrometry
axons
Gray Matter
pathogenesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Schutzer, S. E., Angel, T. E., Liu, T., Schepmoes, A. A., Xie, F., Bergquist, J., ... Coyle, P. K. (2013). Gray Matter Is Targeted in First-Attack Multiple Sclerosis. PLoS One, 8(9), [e66117]. https://doi.org/10.1371/journal.pone.0066117

Gray Matter Is Targeted in First-Attack Multiple Sclerosis. / Schutzer, Steven E.; Angel, Thomas E.; Liu, Tao; Schepmoes, Athena A.; Xie, Fang; Bergquist, Jonas; Vécsei, L.; Zadori, Denes; Camp, David G.; Holland, Bart K.; Smith, Richard D.; Coyle, Patricia K.

In: PLoS One, Vol. 8, No. 9, e66117, 10.09.2013.

Research output: Contribution to journalArticle

Schutzer, SE, Angel, TE, Liu, T, Schepmoes, AA, Xie, F, Bergquist, J, Vécsei, L, Zadori, D, Camp, DG, Holland, BK, Smith, RD & Coyle, PK 2013, 'Gray Matter Is Targeted in First-Attack Multiple Sclerosis', PLoS One, vol. 8, no. 9, e66117. https://doi.org/10.1371/journal.pone.0066117
Schutzer SE, Angel TE, Liu T, Schepmoes AA, Xie F, Bergquist J et al. Gray Matter Is Targeted in First-Attack Multiple Sclerosis. PLoS One. 2013 Sep 10;8(9). e66117. https://doi.org/10.1371/journal.pone.0066117
Schutzer, Steven E. ; Angel, Thomas E. ; Liu, Tao ; Schepmoes, Athena A. ; Xie, Fang ; Bergquist, Jonas ; Vécsei, L. ; Zadori, Denes ; Camp, David G. ; Holland, Bart K. ; Smith, Richard D. ; Coyle, Patricia K. / Gray Matter Is Targeted in First-Attack Multiple Sclerosis. In: PLoS One. 2013 ; Vol. 8, No. 9.
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