Granular C3 dermatosis

Takashi Hashimoto, Daisuke Tsuruta, Atsushi Yasukochi, Hisayoshi Imanishi, Hideharu Sekine, Teizo Fujita, Hideki Wanibuchi, Min Gi, Sarolta Kárpáti, Cassian Sitaru, John J. Zone, Daisuke Endo, Shinichi Abe, Tomoya Nishino, Takehiko Koji, Norito Ishii

Research output: Contribution to journalArticle

7 Citations (Scopus)


There has been no previous systematic study of bullous skin diseases with granular basement membrane zone deposition exclusively of C3. In this study we collected 20 such patients, none of whom showed cutaneous vasculitis histopathologically. Oral dapsone and topical steroids were effective. Various serological tests detected no autoantibodies or autoantigens. Direct immunofluorescence for various complement components revealed deposition only of C3 and C5–C9, indicating that no known complement pathways were involved. Studies of in situ hybridization and micro-dissection with quantitative RT-PCR revealed a slight reduction in expression of C3 in patient epidermis. These patients may represent a new disease entity, for which we propose the term “granular C3 dermatosis”. The mechanism for granular C3 deposition in these patients is unknown, but it is possible that the condition is caused by autoantibodies to skin or aberrant C3 expression in epidermal keratinocytes.

Original languageEnglish
Pages (from-to)748-753
Number of pages6
JournalActa Dermato-Venereologica
Issue number6
Publication statusPublished - Sep 2016


  • Basement membrane zone
  • Bullous disease
  • C3
  • Direct immunofluorescence
  • Granular

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Hashimoto, T., Tsuruta, D., Yasukochi, A., Imanishi, H., Sekine, H., Fujita, T., Wanibuchi, H., Gi, M., Kárpáti, S., Sitaru, C., Zone, J. J., Endo, D., Abe, S., Nishino, T., Koji, T., & Ishii, N. (2016). Granular C3 dermatosis. Acta Dermato-Venereologica, 96(6), 748-753.