Granular C3 dermatosis

Takashi Hashimoto, Daisuke Tsuruta, Atsushi Yasukochi, Hisayoshi Imanishi, Hideharu Sekine, Teizo Fujita, Hideki Wanibuchi, Min Gi, S. Kárpáti, Cassian Sitaru, John J. Zone, Daisuke Endo, Shinichi Abe, Tomoya Nishino, Takehiko Koji, Norito Ishii

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

There has been no previous systematic study of bullous skin diseases with granular basement membrane zone deposition exclusively of C3. In this study we collected 20 such patients, none of whom showed cutaneous vasculitis histopathologically. Oral dapsone and topical steroids were effective. Various serological tests detected no autoantibodies or autoantigens. Direct immunofluorescence for various complement components revealed deposition only of C3 and C5–C9, indicating that no known complement pathways were involved. Studies of in situ hybridization and micro-dissection with quantitative RT-PCR revealed a slight reduction in expression of C3 in patient epidermis. These patients may represent a new disease entity, for which we propose the term “granular C3 dermatosis”. The mechanism for granular C3 deposition in these patients is unknown, but it is possible that the condition is caused by autoantibodies to skin or aberrant C3 expression in epidermal keratinocytes.

Original languageEnglish
Pages (from-to)748-753
Number of pages6
JournalActa Dermato-Venereologica
Volume96
Issue number6
DOIs
Publication statusPublished - Sep 1 2016

Fingerprint

Skin Diseases
Autoantibodies
Vesiculobullous Skin Diseases
Dapsone
Direct Fluorescent Antibody Technique
Skin
Autoantigens
Serologic Tests
Vasculitis
Keratinocytes
Basement Membrane
Epidermis
In Situ Hybridization
Dissection
Steroids
Polymerase Chain Reaction

Keywords

  • Basement membrane zone
  • Bullous disease
  • C3
  • Direct immunofluorescence
  • Granular

ASJC Scopus subject areas

  • Dermatology

Cite this

Hashimoto, T., Tsuruta, D., Yasukochi, A., Imanishi, H., Sekine, H., Fujita, T., ... Ishii, N. (2016). Granular C3 dermatosis. Acta Dermato-Venereologica, 96(6), 748-753. https://doi.org/10.2340/00015555-2379

Granular C3 dermatosis. / Hashimoto, Takashi; Tsuruta, Daisuke; Yasukochi, Atsushi; Imanishi, Hisayoshi; Sekine, Hideharu; Fujita, Teizo; Wanibuchi, Hideki; Gi, Min; Kárpáti, S.; Sitaru, Cassian; Zone, John J.; Endo, Daisuke; Abe, Shinichi; Nishino, Tomoya; Koji, Takehiko; Ishii, Norito.

In: Acta Dermato-Venereologica, Vol. 96, No. 6, 01.09.2016, p. 748-753.

Research output: Contribution to journalArticle

Hashimoto, T, Tsuruta, D, Yasukochi, A, Imanishi, H, Sekine, H, Fujita, T, Wanibuchi, H, Gi, M, Kárpáti, S, Sitaru, C, Zone, JJ, Endo, D, Abe, S, Nishino, T, Koji, T & Ishii, N 2016, 'Granular C3 dermatosis', Acta Dermato-Venereologica, vol. 96, no. 6, pp. 748-753. https://doi.org/10.2340/00015555-2379
Hashimoto T, Tsuruta D, Yasukochi A, Imanishi H, Sekine H, Fujita T et al. Granular C3 dermatosis. Acta Dermato-Venereologica. 2016 Sep 1;96(6):748-753. https://doi.org/10.2340/00015555-2379
Hashimoto, Takashi ; Tsuruta, Daisuke ; Yasukochi, Atsushi ; Imanishi, Hisayoshi ; Sekine, Hideharu ; Fujita, Teizo ; Wanibuchi, Hideki ; Gi, Min ; Kárpáti, S. ; Sitaru, Cassian ; Zone, John J. ; Endo, Daisuke ; Abe, Shinichi ; Nishino, Tomoya ; Koji, Takehiko ; Ishii, Norito. / Granular C3 dermatosis. In: Acta Dermato-Venereologica. 2016 ; Vol. 96, No. 6. pp. 748-753.
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