Graft-versus-host disease in bone marrow transplantation: Experimental, laboratory, and clinical contributions of the last few years

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Graft-vcrsus-host disease (GVHD) is a major and often lethal complication of bone marrow transplantation. Research of the past few years has greatly expanded our understanding of the disease and enriched the arsenal of preventive and therapeutic procedures. The present review attempts to give a survey of experimental and clinical GVHD, updating essential knowledge with the latest information until July 1993. The covered topics include the complex immune pathomechanism of acute and chronic GVHD in murine models, the pathogenic role of major, minor, and other antigenic disparities, laboratory markers predicting GVHD, factors influencing appearance and course of the disease, the relationship between GVHD and the graft-versus-leukemia effect, and novel experimental and clinically tested preventive and therapeutic modalities. Finally, the authors set forth their perspective on the most relevant questions in GVHD-related research.

Original languageEnglish
Pages (from-to)309-320
Number of pages12
JournalInternational Archives of Allergy and Immunology
Volume102
Issue number4
DOIs
Publication statusPublished - 1993

Fingerprint

Graft vs Host Disease
Bone Marrow Transplantation
Transplants
Antigen-Antibody Complex
Research
Leukemia
Biomarkers
Therapeutics

Keywords

  • Bone marrow transplantation conditioning
  • Combination chemotherapy
  • Cord blood hematopoietic cells
  • Cytokines
  • Cytotoxic T lymphocyte precursors
  • Graft-versus-host disease
  • Histocompatibility
  • Lymphocytes
  • Natural killer cells
  • T cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

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abstract = "Graft-vcrsus-host disease (GVHD) is a major and often lethal complication of bone marrow transplantation. Research of the past few years has greatly expanded our understanding of the disease and enriched the arsenal of preventive and therapeutic procedures. The present review attempts to give a survey of experimental and clinical GVHD, updating essential knowledge with the latest information until July 1993. The covered topics include the complex immune pathomechanism of acute and chronic GVHD in murine models, the pathogenic role of major, minor, and other antigenic disparities, laboratory markers predicting GVHD, factors influencing appearance and course of the disease, the relationship between GVHD and the graft-versus-leukemia effect, and novel experimental and clinically tested preventive and therapeutic modalities. Finally, the authors set forth their perspective on the most relevant questions in GVHD-related research.",
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AU - Szebeni, J.

AU - Petrányi, G.

PY - 1993

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