GPR50 is not associated with childhood-onset mood disorders in a large sample of Hungarian families

Yu Feng, Karen Wigg, Nicole King, Ágnes Vetró, Eniko Kiss, Krisztina Kapornai, László Mayer, Júlia Gádoros, James L. Kennedy, Maria Kovacs, Cathy L. Barr, István Benák, Viola Kothencné Osváth, Edit Dombovári, Emília Kaczvinszky, Ildikó Baji, Zsuzsa Tamás, Márta Besnyõ, Judit Székely

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6 Citations (Scopus)

Abstract

We investigated the relationship of the gene for the X-linked orphan G protein-coupled receptor (GPR50) to childhood-onset mood disorders in a sample of 384 families with 468 affected children and adolescents collected in Hungary. Our choice of this gene for study was based on a previous report of an association of GPR50 with bipolar disorder and major depressive disorder. A significant association with the deletion allele of an insertion/deletion polymorphism (Δ502-505) located in exon 2 had been reported in a sample of 226 patients with major depressive disorder and 264 patients with bipolar disorder. The association was more significant in females compared with males in those samples. We used for this study a polymorphism in complete linkage disequilibrium with the Δ502-505 polymorphism, ThrAla (rs561077), and two additional polymorphisms, ValIle (rs13440581) and an intronic polymorphism (rs2072621). We found no evidence for an association for the markers analyzed individually, nor for haplotypes of these markers. Further, we found no evidence of association when the results were analyzed in girls only (n=215). We, therefore, failed to replicate the previous association of this gene with mood disorders.

Original languageEnglish
Pages (from-to)347-350
Number of pages4
JournalPsychiatric genetics
Volume17
Issue number6
DOIs
Publication statusPublished - Dec 1 2007

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Keywords

  • Child
  • Depression
  • Genetics
  • Mood disorders
  • X chromosome
  • X-linked orphan G protein-coupled receptor

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Feng, Y., Wigg, K., King, N., Vetró, Á., Kiss, E., Kapornai, K., Mayer, L., Gádoros, J., Kennedy, J. L., Kovacs, M., Barr, C. L., Benák, I., Osváth, V. K., Dombovári, E., Kaczvinszky, E., Baji, I., Tamás, Z., Besnyõ, M., & Székely, J. (2007). GPR50 is not associated with childhood-onset mood disorders in a large sample of Hungarian families. Psychiatric genetics, 17(6), 347-350. https://doi.org/10.1097/YPG.0b013e3281ac232f