GPC, CD and sedimentation analysis of poly-Lys and branched chain poly-Lys-poly-DL-Ala polypeptides

F. Hudecz, P. Kovács, S. Kutassi-Kovács, J. Kajtár

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Three different poly-L-lysine (pLys) samples and a branched polypeptide poly-[L-Lys-(DL-Ala)m] (poly-L-Lys-poly-DL-Ala, AK) were synthetized. Relative molar mass distribution, its average and the degree of polymerisation were determined by sedimentation analysis and gel permeation chromatography (GPC). The conformation of the polymers in solution was studied by circular dichroism (CD) spectroscopy at various pH values and ionic strengths. The data obtained by different methods were compared.

Original languageEnglish
Pages (from-to)208-212
Number of pages5
JournalColloid & Polymer Science
Issue number3
Publication statusPublished - Mar 1 1984



  • GPC of synthetic polypeptides
  • Poly-L-Lys
  • branched polypeptides
  • poly-L-Lys-poly-DL-Ala
  • sedimentation analysis

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Colloid and Surface Chemistry
  • Materials Chemistry

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