Gonadotropin releasing hormone (GnRH) is not degraded by intact pituitary tissue in vitro

Károly Nikolics, Balázs Szõke, György Kéri, István Teplán

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The possible degradation of GnRH by intact pituitary tissue was investigated. Trypsin-, collagenase- and mechanically dispersed pituitary cells in culture and fresh pituitaries cut into eight segments were incubated with specifically tritiated GnRH or unlabeled GnRH which were detected by HPLC and RIA in incubation media. Degradation of GnRH could not be detected by either method during incubations with any of the pituitary cell cultures or fresh tissue. The results suggest that pituitary degradation is not involved in the regulation of circulating levels of GnRH.

Original languageEnglish
Pages (from-to)1028-1035
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume114
Issue number3
DOIs
Publication statusPublished - Aug 12 1983

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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