Gonadal sex steroid status and bone health in middle-aged and elderly European men

D. Vanderschueren, S. R. Pye, K. Venken, H. Borghs, J. Gaytant, I. T. Huhtaniemi, J. E. Adams, K. A. Ward, G. Bártfai, F. F. Casanueva, J. D. Finn, G. Forti, A. Giwercman, T. S. Han, K. Kula, F. Labrie, M. E J Lean, N. Pendleton, M. Punab, A. J. SilmanF. C W Wu, T. W. O'Neill, S. Boonen

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The influence of sex steroids on calcaneal quantitative ultrasound (QUS) parameters was assessed in a population sample of middle-aged and elderly European men. Higher free and total E2 though not testosterone, were independently associated with higher QUS parameters. Introduction: The aim of this study was to investigate the association between QUS parameters and sex steroids in middle-aged and elderly European men. Methods: Three thousand one hundred forty-one men aged between 40 and 79 years were recruited from eight European centres for participation in a study of male ageing: the European Male Ageing Study. Subjects were invited by letter to attend for an interviewer-administered questionnaire, blood sample and QUS of the calcaneus (Hologic-SAHARA). Blood was assessed for sex steroids including oestradiol (E2), testosterone (T), free and bio-available E2 and T and sex hormone binding globulin (SHBG). Results: Serum total T was not associated with any of the QUS parameters. Free T and both free and total E 2 were positively related to all QUS readings, while SHBG concentrations were negatively associated. These relationships were observed in both older and younger (2 and SHBG, though not free T, remained independently associated with the QUS parameters. After further adjustment for IGF-1, however, the association with SHBG became non-significant. Conclusion: Higher free and total E2 are associated with bone health not only among the elderly but also middle-aged European men.

Original languageEnglish
Pages (from-to)1331-1339
Number of pages9
JournalOsteoporosis International
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 2010

Fingerprint

Sex Hormone-Binding Globulin
Health Status
Steroids
Bone and Bones
Testosterone
Calcaneus
Insulin-Like Growth Factor I
Reading
Estradiol
Interviews
Health
Serum
Population

Keywords

  • Epidemiology
  • Oestradiol
  • Sex steroids
  • SHBG
  • Testosterone
  • Ultrasound

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Vanderschueren, D., Pye, S. R., Venken, K., Borghs, H., Gaytant, J., Huhtaniemi, I. T., ... Boonen, S. (2010). Gonadal sex steroid status and bone health in middle-aged and elderly European men. Osteoporosis International, 21(8), 1331-1339. https://doi.org/10.1007/s00198-009-1144-2

Gonadal sex steroid status and bone health in middle-aged and elderly European men. / Vanderschueren, D.; Pye, S. R.; Venken, K.; Borghs, H.; Gaytant, J.; Huhtaniemi, I. T.; Adams, J. E.; Ward, K. A.; Bártfai, G.; Casanueva, F. F.; Finn, J. D.; Forti, G.; Giwercman, A.; Han, T. S.; Kula, K.; Labrie, F.; Lean, M. E J; Pendleton, N.; Punab, M.; Silman, A. J.; Wu, F. C W; O'Neill, T. W.; Boonen, S.

In: Osteoporosis International, Vol. 21, No. 8, 08.2010, p. 1331-1339.

Research output: Contribution to journalArticle

Vanderschueren, D, Pye, SR, Venken, K, Borghs, H, Gaytant, J, Huhtaniemi, IT, Adams, JE, Ward, KA, Bártfai, G, Casanueva, FF, Finn, JD, Forti, G, Giwercman, A, Han, TS, Kula, K, Labrie, F, Lean, MEJ, Pendleton, N, Punab, M, Silman, AJ, Wu, FCW, O'Neill, TW & Boonen, S 2010, 'Gonadal sex steroid status and bone health in middle-aged and elderly European men', Osteoporosis International, vol. 21, no. 8, pp. 1331-1339. https://doi.org/10.1007/s00198-009-1144-2
Vanderschueren D, Pye SR, Venken K, Borghs H, Gaytant J, Huhtaniemi IT et al. Gonadal sex steroid status and bone health in middle-aged and elderly European men. Osteoporosis International. 2010 Aug;21(8):1331-1339. https://doi.org/10.1007/s00198-009-1144-2
Vanderschueren, D. ; Pye, S. R. ; Venken, K. ; Borghs, H. ; Gaytant, J. ; Huhtaniemi, I. T. ; Adams, J. E. ; Ward, K. A. ; Bártfai, G. ; Casanueva, F. F. ; Finn, J. D. ; Forti, G. ; Giwercman, A. ; Han, T. S. ; Kula, K. ; Labrie, F. ; Lean, M. E J ; Pendleton, N. ; Punab, M. ; Silman, A. J. ; Wu, F. C W ; O'Neill, T. W. ; Boonen, S. / Gonadal sex steroid status and bone health in middle-aged and elderly European men. In: Osteoporosis International. 2010 ; Vol. 21, No. 8. pp. 1331-1339.
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