Glikoprotein hormon alpha-alegység elválasztás nem funkcionáló hypophysisdaganatokban.

Translated title of the contribution: Glycoprotein hormone alpha-subunit secretion in non-functioning pituitary adenomas

Research output: Contribution to journalReview article

Abstract

The aim of the present study was to investigate the prevalence of elevated free glycoprotein hormone alpha-subunit in different pituitary adenomas, to establish the diagnostic value of the basal and stimulated free alpha-subunit secretion in non-functioning adenomas. Serum basal levels of alpha-subunit were increased in 1 of 22 untreated, in 1 of 16 operated patients with non-functioning adenoma, in 6 of 28 untreated, in 1 of 7 operated patients with acromegaly, in 0 of 5 untreated prolactinomas and in 0 of 1 untreated gonadotrop adenoma. Overall free alpha-subunit levels were increased in 9 of 79 cases (11.4%). In 6 of 9 patients with untreated non-functioning adenoma thyrotrop hormone releasing hormone caused an abnormal--paradox--elevation of serum alpha-subunit. These data indicate that measurement of basal and stimulated alpha-subunit is of relatively poor value in the diagnosis of non-functioning pituitary adenomas. The transsphenoidal surgery did not resulted in a change of alpha-subunit secretion neither in patients with non-functioning adenoma nor with acromegaly. The present data confirm the view that non-functioning pituitary adenomas are not homogeneous since this subset of tumors includes adenomas that either do not secrete measurable amounts of free alpha-subunit or produce normal or supranormal amounts of subunits as consequence of still undefined biosynthetic abnormalities.

Translated title of the contributionGlycoprotein hormone alpha-subunit secretion in non-functioning pituitary adenomas
Original languageHungarian
Pages (from-to)2655-2659
Number of pages5
JournalOrvosi hetilap
Volume138
Issue number42
Publication statusPublished - Oct 19 1997

ASJC Scopus subject areas

  • Medicine(all)

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